{"id":27572,"date":"2015-05-01T00:00:00","date_gmt":"2018-12-03T21:54:44","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/diet-rich-in-high-glucoraphanin-broccoli-reduces-plasma-ldl\/"},"modified":"2018-12-03T22:54:44","modified_gmt":"2018-12-03T21:54:44","slug":"diet-rich-in-high-glucoraphanin-broccoli-reduces-plasma-ldl","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/diet-rich-in-high-glucoraphanin-broccoli-reduces-plasma-ldl\/","title":{"rendered":"Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomised controlled trials."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>SCOPE<\/strong><br \/>\nCruciferous-rich diets have been associated with reduction in plasma LDL-cholesterol (LDL-C), which may be due to the action of isothiocyanates derived from glucosinolates that accumulate in these vegetables. This study tests the hypothesis that a diet rich in high glucoraphanin (HG) broccoli will reduce plasma LDL-C.<\/p>\n<p style=\"text-align:justify\"><strong>METHODS AND RESULTS<\/strong><br \/>\nOne hundred and thirty volunteers were recruited to two independent double-blind, randomly allocated parallel dietary intervention studies, and were assigned to consume either 400 g standard broccoli or 400 g HG broccoli per week for 12&Acirc;&nbsp;weeks. Plasma lipids were quantified before and after the intervention. In study 1 (37 volunteers), the HG broccoli diet reduced plasma LDL-C by 7.1% (95% CI: -1.8%, -12.3%, p = 0.011), whereas standard broccoli reduced LDL-C by 1.8% (95% CI +3.9%, -7.5%, ns). In study 2 (93 volunteers), the HG broccoli diet resulted in a reduction of 5.1% (95% CI: -2.1%, -8.1%, p = 0.001), whereas standard broccoli reduced LDL-C by 2.5% (95% CI: +0.8%, -5.7%, ns). When data from the two studies were combined the reduction in LDL-C by the HG broccoli was significantly greater than standard broccoli (p = 0.031).<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSION<\/strong><br \/>\nEvidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-27572","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Food and Health Programme, Institute of Food Research, Norwich, UK.\r\nrichard.mithen@ifr.ac.uk","annee":"2015","mois":"5","numero":"59:5","page":"918-26","auteurs":[{"ID":27566,"post_author":"0","post_date":"2018-12-03 22:54:39","post_date_gmt":"2018-12-03 21:54:39","post_content":"","post_title":"Charlotte N 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