{"id":27363,"date":"2015-04-01T00:00:00","date_gmt":"2018-12-03T21:51:50","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-association-between-carbohydrate-rich-foods-and-risk\/"},"modified":"2018-12-03T22:51:50","modified_gmt":"2018-12-03T21:51:50","slug":"the-association-between-carbohydrate-rich-foods-and-risk","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-association-between-carbohydrate-rich-foods-and-risk\/","title":{"rendered":"The Association between Carbohydrate-Rich Foods and Risk of Cardiovascular Disease Is Not Modified by Genetic Susceptibility to Dyslipidemia as Determined by 80 Validated Variants."},"content":{"rendered":"

BACKGROUND<\/strong>: It is still unclear whether carbohydrate consumption is associated with cardiovascular disease (CVD) risk. Genetic susceptibility might modify the associations between dietary intakes and disease risk.<\/p>\n

OBJECTIVES<\/strong>: The aim was to examine the association between the consumption of carbohydrate-rich foods (vegetables, fruits and berries, juice, potatoes, whole grains, refined grains, cookies and cakes, sugar and sweets, and sugar-sweetened beverages) and the risk of incident ischemic CVD (iCVD; coronary events and ischemic stroke), and whether these associations differ depending on genetic susceptibility to dyslipidemia.<\/p>\n

METHODS<\/strong>: Among 26,445 individuals (44-74 years; 62% females) from the Malmö Diet and Cancer Study cohort, 2,921 experienced an iCVD event during a mean follow-up time of 14 years. At baseline, dietary data were collected using a modified diet history method, and clinical risk factors were measured in 4,535 subjects. We combined 80 validated genetic variants associated with triglycerides and HDL-C or LDL-C, into genetic risk scores and examined the interactions between dietary intakes and genetic risk scores on the incidence of iCVD.<\/p>\n

RESULTS<\/strong>: Subjects in the highest intake quintile for whole grains had a 13% (95% CI: 3-23%; p-trend: 0.002) lower risk for iCVD compared to the lowest quintile. A higher consumption of foods rich in added sugar (sugar and sweets, and sugar-sweetened beverages) had a significant cross-sectional association with higher triglyceride concentrations and lower HDL-C concentrations. A stronger positive association between a high consumption of sugar and sweets on iCVD risk was observed among those with low genetic risk score for triglycerides (p-interaction=0.05).<\/p>\n

CONCLUSION<\/strong>: In this prospective cohort study that examined food sources of carbohydrates, individuals with a high consumption of whole grains had a decreased risk of iCVD. No convincing evidence of an interaction between genetic susceptibility for dyslipidemia, measured as genetic risk scores of dyslipidemia-associated variants, and the consumption of carbohydrate-rich foods on iCVD risk was observed.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-27363","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences Malm\u00f6, Lund University, Malm\u00f6, Sweden.","annee":"2015","mois":"4","numero":"10:4","page":"e0126104","auteurs":[{"ID":5104,"post_author":"0","post_date":"2018-12-03 17:24:17","post_date_gmt":"2018-12-03 16:24:17","post_content":"","post_title":"Ulrika Ericson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ulrika-ericson","to_ping":"","pinged":"","post_modified":"2018-12-03 17:24:17","post_modified_gmt":"2018-12-03 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Drake","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"isabel-drake","to_ping":"","pinged":"","post_modified":"2018-12-03 17:24:18","post_modified_gmt":"2018-12-03 16:24:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/isabel-drake\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":5107,"post_author":"0","post_date":"2018-12-03 17:24:19","post_date_gmt":"2018-12-03 16:24:19","post_content":"","post_title":"Bo Gullberg","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bo-gullberg","to_ping":"","pinged":"","post_modified":"2018-12-03 17:24:19","post_modified_gmt":"2018-12-03 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