{"id":26235,"date":"2015-06-01T00:00:00","date_gmt":"2018-12-03T21:35:08","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/is-the-association-between-vitamin-d-and-cardiovascular-disease\/"},"modified":"2018-12-03T22:35:08","modified_gmt":"2018-12-03T21:35:08","slug":"is-the-association-between-vitamin-d-and-cardiovascular-disease","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/is-the-association-between-vitamin-d-and-cardiovascular-disease\/","title":{"rendered":"Is the Association between Vitamin D and Cardiovascular Disease Risk Confounded by Obesity? Evidence from the Andhra Pradesh Children and Parents Study (APCAPS)."},"content":{"rendered":"<p style=\"text-align: justify\"><strong>BACKGROUND: <\/strong>Evidence of an association between serum vitamin D and cardiovascular disease risk is inconsistent and comes predominantly from studies in high-income settings. We assessed the association between serum levels of 25-hydroxyvitamin D3 (25(OH)D) and cardiovascular disease risk factors in a population of young Indian adults.<\/p>\n<p style=\"text-align: justify\"><strong>METHODS: <\/strong>Cross-sectional analyses of data from APCAPS (Andhra Pradesh Children and Parents Study); a prospective birth cohort study in rural south India. Participants were 1038 (40.3% females) adults aged 18-24 years. Main outcome measures were blood pressures, fasting serum lipids (cholesterols and triglycerides), fasting glucose, insulin, measures of arterial stiffness (aortic augmentation index and aortic pulse wave velocity (aPWV)), carotid intima-media thickness, body mass index (BMI) and body fat (dual X-ray absorptiometry).<\/p>\n<p style=\"text-align: justify\"><strong>RESULTS: <\/strong>Vitamin D deficiency (&le;20ng\/ml) was observed in 41.1% of this lean (mean BMI: 19.5) and active (mean minutes of moderate or vigorous physical activity per day: 186) population. Vitamin D deficiency was associated with higher median body fat in both males (15.9% body fat in vitamin D deficient males vs. 14.6% in non-deficient males, p&lt;0.05) and females (29.1% body fat in vitamin D deficient females vs. 27.8% in non-deficient females, p&lt;0.05) but no associations were observed between vitamin D deficiency and mean BMI or median fat mass index (FMI). Except a weak inverse association with fasting insulin in males, there was no clear association between serum vitamin D levels and cardiovascular disease risk factors in fully adjusted models.<\/p>\n<p style=\"text-align: justify\"><strong>CONCLUSIONS: <\/strong>We did not find clear evidence for an association between serum vitamin D levels and cardiovascular disease risk factors. Our results, consistent with the limited evidence from randomised trials of vitamin D supplementation and Mendelian randomisation experiments, suggest that the postulated link between serum vitamin D and cardiovascular disease may be non-causal. Instead, it may be attributable to confounding by lifestyle factors such as obesity and physical inactivity which may provide more fruitful targets for cardiovascular disease prevention.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-26235","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.\r\nchris.baker@lshtm.ac.uk","annee":"2015","mois":"6","numero":"10:6","page":"e0129468","auteurs":[{"ID":26222,"post_author":"0","post_date":"2018-12-03 22:34:58","post_date_gmt":"2018-12-03 21:34:58","post_content":"","post_title":"Yoav Ben-shlomo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yoav-ben-shlomo","to_ping":"","pinged":"","post_modified":"2018-12-03 22:34:58","post_modified_gmt":"2018-12-03 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Prabhakaran","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dorairaj-prabhakaran","to_ping":"","pinged":"","post_modified":"2018-12-03 15:59:30","post_modified_gmt":"2018-12-03 14:59:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dorairaj-prabhakaran\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":26223,"post_author":"0","post_date":"2018-12-03 22:34:59","post_date_gmt":"2018-12-03 21:34:59","post_content":"","post_title":"George Davey Smith","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"george-davey-smith","to_ping":"","pinged":"","post_modified":"2018-12-03 22:34:59","post_modified_gmt":"2018-12-03 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