{"id":25450,"date":"2015-07-01T00:00:00","date_gmt":"2018-12-03T21:20:29","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mediterranean-diet-and-preserved-brain-structural-connectivity\/"},"modified":"2018-12-03T22:20:29","modified_gmt":"2018-12-03T21:20:29","slug":"mediterranean-diet-and-preserved-brain-structural-connectivity","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mediterranean-diet-and-preserved-brain-structural-connectivity\/","title":{"rendered":"Mediterranean diet and preserved brain structural connectivity in older subjects."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>BACKGROUND<\/strong><br \/>\nThe Mediterranean diet (MeDi) has been related to a lower risk of Alzheimer&#039;s disease; yet, the underlying mechanisms are unknown. We hypothesized that protection against neurodegeneration would translate into higher gray matter volumes, whereas a specific association with preserved white matter microstructure would suggest alternative mechanisms (e.g., vascular pathways).<\/p>\n<p style=\"text-align:justify\"><strong>METHODS<\/strong><br \/>\nWe included 146 participants from the Bordeaux Three-City study nondemented when they completed a dietary questionnaire and who underwent a 3-T magnetic resonance imaging at an average of 9 years later, including diffusion tensor imaging.<\/p>\n<p style=\"text-align:justify\"><strong>RESULTS<\/strong><br \/>\nIn multivariate voxel-by-voxel analyses, adherence to the MeDi was significantly associated with preserved white matter microstructure in extensive areas, a gain in structural connectivity that was related to strong cognitive benefits. In contrast, we found no relation with gray matter volumes.<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSIONS<\/strong><br \/>\nThe MeDi appears to benefit brain health through preservation of structural connectivity. Potential mediation by a favorable impact on brain vasculature deserves further research.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-25450","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, University of Bordeaux, Bordeaux, France.","annee":"2015","mois":"7","numero":"","page":"","auteurs":[{"ID":23194,"post_author":"0","post_date":"2018-12-03 21:20:25","post_date_gmt":"2018-12-03 20:20:25","post_content":"","post_title":"Pascale Barberger-Gateau","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pascale-barberger-gateau","to_ping":"","pinged":"","post_modified":"2018-12-03 21:20:25","post_modified_gmt":"2018-12-03 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