{"id":25167,"date":"2015-08-01T00:00:00","date_gmt":"2018-12-03T21:13:24","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plasma-carotenoids-are-inversely-associated-with-dementia\/"},"modified":"2018-12-03T22:13:24","modified_gmt":"2018-12-03T21:13:24","slug":"plasma-carotenoids-are-inversely-associated-with-dementia","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plasma-carotenoids-are-inversely-associated-with-dementia\/","title":{"rendered":"Plasma Carotenoids Are Inversely Associated With Dementia Risk in an Elderly French Cohort."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>BACKGROUND<\/strong><br \/>\nAlthough intake of fruits and vegetables has been associated with a decreased risk of dementia, studies focusing on nutrients underlying this association are lacking. Our objective was to analyze the relation between plasma carotenoids and the risk of dementia and Alzheimer&#039;s disease (AD) in French elderly community dwellers.<\/p>\n<p style=\"text-align:justify\"><strong>METHODS<\/strong><br \/>\nThe study population consisted of 1,092 nondemented older participants, from the Three-City-Bordeaux cohort followed for up to 10 years (range: 1.8-10.8 years, median: 9.5 years). Dementia and AD were diagnosed by a committee of neurologists. The concentration of plasma carotenoids (beta-carotene, alpha-carotene, lycopene, lutein, zeaxanthin, and beta-cryptoxanthin) was determined at baseline. Longitudinal analyses of the association between each plasma carotenoid, either crude or expressed as a ratio to plasma lipids (total cholesterol + triglycerides), and the risk of dementia or AD were performed by multivariate Cox models.<\/p>\n<p style=\"text-align:justify\"><strong>RESULTS<\/strong><br \/>\nDuring follow-up, 199 dementia cases, including 132 AD, occurred. After adjustment for sociodemographic data, diet quality, and clinical variables, including baseline cognitive performances, only higher lutein concentration, considered as a function of plasma lipids, was consistently significantly associated with a decreased risk of all-cause dementia and AD (hazard ratio = 0.808, 95% confidence interval = 0.671-0.973, p = .024 and hazard ratio = 0.759, 95% confidence interval = 0.600-0.960, p = .021, respectively for +1 SD).<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSION<\/strong><br \/>\nThis large cohort of older participants suggests that maintaining higher concentrations of lutein in respect to plasma lipids may moderately decrease the risk of dementia and AD.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-25167","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Centre INSERM U897-Epidemiologie-Biostatistique, INSERM, ISPED, Bordeaux, France. Centre INSERM U897-Epidemiologie-Biostatistique, Univ. Bordeaux, ISPED, Bordeaux, France. Catherine.Feart@isped.u-bordeaux2.fr","annee":"2015","mois":"8","numero":"","page":"","auteurs":[{"ID":23194,"post_author":"0","post_date":"2018-12-03 21:20:25","post_date_gmt":"2018-12-03 20:20:25","post_content":"","post_title":"Pascale Barberger-Gateau","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pascale-barberger-gateau","to_ping":"","pinged":"","post_modified":"2018-12-03 21:20:25","post_modified_gmt":"2018-12-03 20:20:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pascale-barberger-gateau\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":2180,"post_author":"0","post_date":"2018-12-03 16:53:09","post_date_gmt":"2018-12-03 15:53:09","post_content":"","post_title":"Catherine Feart","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"catherine-feart","to_ping":"","pinged":"","post_modified":"2018-12-03 16:53:09","post_modified_gmt":"2018-12-03 15:53:09","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/catherine-feart\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":2181,"post_author":"0","post_date":"2018-12-03 16:53:09","post_date_gmt":"2018-12-03 15:53:09","post_content":"","post_title":"C\u00e9cilia Samieri","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cecilia-samieri","to_ping":"","pinged":"","post_modified":"2018-12-03 16:53:09","post_modified_gmt":"2018-12-03 15:53:09","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/cecilia-samieri\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3110,"post_author":"0","post_date":"2018-12-03 17:02:24","post_date_gmt":"2018-12-03 16:02:24","post_content":"","post_title":"Catherine Helmer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"catherine-helmer","to_ping":"","pinged":"","post_modified":"2018-12-03 17:02:24","post_modified_gmt":"2018-12-03 16:02:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/catherine-helmer\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3111,"post_author":"0","post_date":"2018-12-03 17:02:24","post_date_gmt":"2018-12-03 16:02:24","post_content":"","post_title":"Jean-Fran\u00e7ois Dartigues","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jean-francois-dartigues","to_ping":"","pinged":"","post_modified":"2018-12-03 17:02:24","post_modified_gmt":"2018-12-03 16:02:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jean-francois-dartigues\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":25163,"post_author":"0","post_date":"2018-12-03 22:13:19","post_date_gmt":"2018-12-03 21:13:19","post_content":"","post_title":"Luc Letenneur","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"luc-letenneur","to_ping":"","pinged":"","post_modified":"2018-12-03 22:13:19","post_modified_gmt":"2018-12-03 21:13:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/luc-letenneur\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":25164,"post_author":"0","post_date":"2018-12-03 22:13:20","post_date_gmt":"2018-12-03 21:13:20","post_content":"","post_title":"Wolfgang Schalch","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"wolfgang-schalch","to_ping":"","pinged":"","post_modified":"2018-12-03 22:13:20","post_modified_gmt":"2018-12-03 21:13:20","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/wolfgang-schalch\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":25165,"post_author":"0","post_date":"2018-12-03 22:13:21","post_date_gmt":"2018-12-03 21:13:21","post_content":"","post_title":"St&Atilde;&copy;phane Etheve","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"stphane-etheve","to_ping":"","pinged":"","post_modified":"2018-12-03 22:13:21","post_modified_gmt":"2018-12-03 21:13:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/stphane-etheve\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":25166,"post_author":"0","post_date":"2018-12-03 22:13:22","post_date_gmt":"2018-12-03 21:13:22","post_content":"","post_title":"C&Atilde;&copy;cile Delcourt","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ccile-delcourt","to_ping":"","pinged":"","post_modified":"2018-12-03 22:13:22","post_modified_gmt":"2018-12-03 21:13:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ccile-delcourt\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":6809,"post_author":"0","post_date":"2018-12-03 17:42:11","post_date_gmt":"2018-12-03 16:42:11","post_content":"","post_title":"The journals of gerontology. Series A, Biological sciences and medical sciences","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"the-journals-of-gerontology-series-a-biological-sciences-and-medical-sciences","to_ping":"","pinged":"","post_modified":"2018-12-03 17:42:11","post_modified_gmt":"2018-12-03 16:42:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/the-journals-of-gerontology-series-a-biological-sciences-and-medical-sciences\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Plasma Carotenoids Are Inversely Associated With Dementia Risk in an Elderly French Cohort. - Aprifel<\/title>\n<meta name=\"description\" content=\"Plasma Carotenoids Are Inversely Associated With Dementia Risk in an Elderly French Cohort. - 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