{"id":24822,"date":"2015-09-01T00:00:00","date_gmt":"2018-12-03T21:03:40","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-fruit-consumption-and-folate-deficiency-are-associated\/"},"modified":"2018-12-03T22:03:40","modified_gmt":"2018-12-03T21:03:40","slug":"low-fruit-consumption-and-folate-deficiency-are-associated","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-fruit-consumption-and-folate-deficiency-are-associated\/","title":{"rendered":"Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population."},"content":{"rendered":"<p style=\"text-align:justify\">Several dietary agents, such as micronutrient and non-nutrient components, the so-called bioactive food components, have been shown to display anticancer properties and influence genetic processes. The most common epigenetic change is DNA methylation. Hypomethylation of long interspersed elements (LINE-1) has been associated with an increased risk of several cancers, although conflicting findings have also been observed. The aim of the present study was to test the hypothesis that a low adherence to the Mediterranean diet (MD) and folate deficiency may cause LINE-1 hypomethylation in blood leukocytes of healthy women, and thus genomic instability. One hundred and seventy-seven non-pregnant women were enrolled. Mediterranean diet score (MDS) and folate intake were calculated using a food frequency questionnaire. LINE-1 methylation level was measured by pyrosequencing analysis in three CpG sites of LINE-1 promoter. According to MDS, only 9.6&nbsp;% of subjects achieved a high adherence to MD. Taking into account the use of supplements, there was a high prevalence of folate deficiency (73.4&nbsp;%). Women whose consumption of fruit was below the median value (i.e., &lt;201 gr\/day) were 3.7 times more likely to display LINE-1 hypomethylation than women whose consumption was above the median value (OR 3.7; 95&nbsp;% CI 1.4&ndash;9.5). Similarly, women with folate deficiency were 3.6 times more likely to display LINE-1 hypomethylation than women with no folate deficiency (OR 3.6; 95&nbsp;% CI 1.1&ndash;12.1). A dietary pattern characterized by low fruit consumption and folate deficiency is associated with LINE-1 hypomethylation and with cancer risk.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-24822","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University of Catania, Via S. Sofia 87, 95121 Catania, Italy. agodia@unict.it.","annee":"2015","mois":"9","numero":"10:5","page":"480","auteurs":[{"ID":3971,"post_author":"0","post_date":"2018-12-03 17:11:09","post_date_gmt":"2018-12-03 16:11:09","post_content":"","post_title":"Antonella Agodi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"antonella-agodi","to_ping":"","pinged":"","post_modified":"2018-12-03 17:11:09","post_modified_gmt":"2018-12-03 16:11:09","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/antonella-agodi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3972,"post_author":"0","post_date":"2018-12-03 17:11:10","post_date_gmt":"2018-12-03 16:11:10","post_content":"","post_title":"Martina Barchitta","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"martina-barchitta","to_ping":"","pinged":"","post_modified":"2018-12-03 17:11:10","post_modified_gmt":"2018-12-03 16:11:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/martina-barchitta\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":5305,"post_author":"0","post_date":"2018-12-03 17:26:30","post_date_gmt":"2018-12-03 16:26:30","post_content":"","post_title":"Annalisa Quattrocchi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"annalisa-quattrocchi","to_ping":"","pinged":"","post_modified":"2018-12-03 17:26:30","post_modified_gmt":"2018-12-03 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Canto","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"carolina-canto","to_ping":"","pinged":"","post_modified":"2018-12-03 22:03:37","post_modified_gmt":"2018-12-03 21:03:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/carolina-canto\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":24820,"post_author":"0","post_date":"2018-12-03 22:03:38","post_date_gmt":"2018-12-03 21:03:38","post_content":"","post_title":"Anna Elisa Marchese","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"anna-elisa-marchese","to_ping":"","pinged":"","post_modified":"2018-12-03 22:03:38","post_modified_gmt":"2018-12-03 21:03:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/anna-elisa-marchese\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3974,"post_author":"0","post_date":"2018-12-03 17:11:11","post_date_gmt":"2018-12-03 16:11:11","post_content":"","post_title":"Manlio Vinciguerra","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"manlio-vinciguerra","to_ping":"","pinged":"","post_modified":"2018-12-03 17:11:11","post_modified_gmt":"2018-12-03 16:11:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/manlio-vinciguerra\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":24821,"post_author":"0","post_date":"2018-12-03 22:03:39","post_date_gmt":"2018-12-03 21:03:39","post_content":"","post_title":"Genes &amp; nutrition","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"genes-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-03 22:03:39","post_modified_gmt":"2018-12-03 21:03:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/genes-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population. - Aprifel<\/title>\n<meta name=\"description\" content=\"Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population. - 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