{"id":24781,"date":"2015-09-01T00:00:00","date_gmt":"2018-12-03T21:02:31","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/fruits-vegetables-and-lung-cancer-risk-a-systematic-review\/"},"modified":"2018-12-03T22:02:31","modified_gmt":"2018-12-03T21:02:31","slug":"fruits-vegetables-and-lung-cancer-risk-a-systematic-review","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/fruits-vegetables-and-lung-cancer-risk-a-systematic-review\/","title":{"rendered":"Fruits, vegetables and lung cancer risk: a systematic review and meta-analysis."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>BACKGROUND<\/strong><br \/>\nLung cancer is the most common cause of cancer death. Fruits and vegetables containing carotenoids and other antioxidants have been hypothesized to decrease lung cancer risk. As part of the <span class='tooltipsall tooltip_post_id_80442 classtoolTips80442'>WCRF<\/span> International Continuous Update Project, we conducted a systematic review and meta-analysis of prospective studies.<\/p>\n<p style=\"text-align:justify\"><strong>METHODS<\/strong><br \/>\nWe searched PubMed and several databases up to December 2014 for prospective studies. We conducted meta-analyses comparing highest and lowest intakes and dose-response meta-analyses to estimate summary relative risks (RRs) and 95% confidence intervals (CIs), and examine possible nonlinear associations. We combined results from the Pooling Project with the studies we identified to increase the statistical power of our analysis.<\/p>\n<p style=\"text-align:justify\"><strong>RESULTS<\/strong><br \/>\nWhen comparing the highest with the lowest intakes, the summary RR estimates were 0.86(95% CI: 0.78-0.94; n(studies)=18) for fruits and vegetables, 0.92(95% CI: 0.87-0.97; n=25) for vegetables and 0.82(95% CI: 0.76-0.89; n=29) for fruits. The association with fruit and vegetable intake was marginally significant in current smokers and inverse but not significant in former or never smokers. Significant inverse dose-response associations were observed for each 100 g\/day increase: for fruits and vegetables (RR=0.96; 95% CI= 0.94-0.98, I(2) =64%, n=14, N(cases)=9609), vegetables (RR=0.94; 95% CI= 0.89-0.98, I(2) =48%, n=20, N=12 563), and fruits (RR=0.92; 95% CI= 0.89-0.95, I(2) =57%, n=23, N=14506). Our results were consistent among the different type of fruits and vegetables. The strength of the association differed across locations. There was evidence of a non-linear relationship (p&lt;0.01) between fruit and vegetable intake and lung cancer risk showing that no further benefit is obtained when increasing consumption above approximately 400 g per day.<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSIONS<\/strong><br \/>\nEliminating tobacco smoking is the best strategy to prevent lung cancer. Although residual confounding by smoking cannot be ruled out, the current evidence from prospective studies is consistent with a protective role of fruit and vegetables in lung cancer aetiology.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-24781","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. a.vieira@imperial.ac.uk","annee":"2015","mois":"9","numero":"","page":"","auteurs":[{"ID":4189,"post_author":"0","post_date":"2018-12-03 17:13:16","post_date_gmt":"2018-12-03 16:13:16","post_content":"","post_title":"Darren C Greenwood","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"darren-c-greenwood","to_ping":"","pinged":"","post_modified":"2018-12-03 17:13:16","post_modified_gmt":"2018-12-03 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Rosenblatt","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"deborah-a-navarro-rosenblatt","to_ping":"","pinged":"","post_modified":"2018-12-03 20:19:06","post_modified_gmt":"2018-12-03 19:19:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/deborah-a-navarro-rosenblatt\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9017,"post_author":"0","post_date":"2018-12-03 18:06:26","post_date_gmt":"2018-12-03 17:06:26","post_content":"","post_title":"Teresa Norat","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"teresa-norat","to_ping":"","pinged":"","post_modified":"2018-12-03 18:06:26","post_modified_gmt":"2018-12-03 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Vingeliene","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"snieguole-vingeliene","to_ping":"","pinged":"","post_modified":"2018-12-03 20:19:03","post_modified_gmt":"2018-12-03 19:19:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/snieguole-vingeliene\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12075,"post_author":"0","post_date":"2018-12-03 18:42:27","post_date_gmt":"2018-12-03 17:42:27","post_content":"","post_title":"D S M Chan","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"d-s-m-chan","to_ping":"","pinged":"","post_modified":"2018-12-03 18:42:27","post_modified_gmt":"2018-12-03 17:42:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/d-s-m-chan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19277,"post_author":"0","post_date":"2018-12-03 20:19:05","post_date_gmt":"2018-12-03 19:19:05","post_content":"","post_title":"Christophe Stevens","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"christophe-stevens","to_ping":"","pinged":"","post_modified":"2018-12-03 20:19:05","post_modified_gmt":"2018-12-03 19:19:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/christophe-stevens\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":24780,"post_author":"0","post_date":"2018-12-03 22:02:31","post_date_gmt":"2018-12-03 21:02:31","post_content":"","post_title":"Annals 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