{"id":24537,"date":"2015-09-01T00:00:00","date_gmt":"2018-12-03T20:56:14","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mediterranean-diet-retinopathy-nephropathy-and-microvascular\/"},"modified":"2018-12-03T21:56:14","modified_gmt":"2018-12-03T20:56:14","slug":"mediterranean-diet-retinopathy-nephropathy-and-microvascular","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mediterranean-diet-retinopathy-nephropathy-and-microvascular\/","title":{"rendered":"Mediterranean Diet, Retinopathy, Nephropathy, and Microvascular Diabetes Complications: A Post Hoc Analysis of a Randomized Trial."},"content":{"rendered":"<p style=\"text-align: justify\"><strong>OBJECTIVE:<\/strong> To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat control diet.<\/p>\n<p style=\"text-align: justify\"><strong>RESEARCH DESIGN AND METHODS:<\/strong> This was a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvenci&oacute;n con DIeta MEDiterr&aacute;nea (PREDIMED) study, a multicenter randomized nutritional intervention trial conducted in a population at high cardiovascular risk. Individuals with type 2 diabetes who were free of microvascular complications at enrollment (n = 3,614, aged 55-80 years) were randomly assigned to one of three dietary interventions: MedDiet supplemented with extravirgin olive oil (MedDiet+EVOO), MedDiet supplemented with mixed nuts (MedDiet+Nuts), or a low-fat control diet. Two independent outcomes were considered: new-onset of diabetic retinopathy and nephropathy. Hazard ratios (HRs) were calculated using multivariable-adjusted Cox regression.<\/p>\n<p style=\"text-align: justify\"><strong>RESULTS: <\/strong>During a median follow-up of 6.0 years, we identified 74 new cases of retinopathy and 168 of nephropathy. Compared with the control diet, multivariable-adjusted HRs for diabetic retinopathy were 0.56 (95% CI, 0.32-0.97) for the MedDiet+EVOO and 0.63 (0.35-1.11) for the MedDiet+Nuts. No between-group differences were found for nephropathy. When the yearly updated information on adherence to the MedDiet was considered, the HR for retinopathy in the highest versus the lowest quintile was 0.34 (0.13-0.89; P = 0.001 for trend). No significant associations were found for nephropathy.<\/p>\n<p style=\"text-align: justify\"><strong>CONCLUSIONS:<\/strong> A MedDiet enriched with EVOO may protect against diabetic retinopathy but not diabetic nephropathy.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-24537","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Human Nutrition Unit, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Rovira i Virgili University, Reus, Spain Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III, Madrid, Spain jordi.salas@urv.cat; nancy.babio@urv.cat","annee":"2015","mois":"9","numero":":","page":"","auteurs":[{"ID":1164,"post_author":"0","post_date":"2018-12-03 15:56:56","post_date_gmt":"2018-12-03 14:56:56","post_content":"","post_title":"Ram\u00f3n 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Zanon-Moreno","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"vicente-zanon-moreno","to_ping":"","pinged":"","post_modified":"2018-12-03 21:56:13","post_modified_gmt":"2018-12-03 20:56:13","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/vicente-zanon-moreno\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4546,"post_author":"0","post_date":"2018-12-03 17:18:31","post_date_gmt":"2018-12-03 16:18:31","post_content":"","post_title":"Miguel \u00c1ngel Mu\u00f1oz","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"miguel-angel-munoz","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:31","post_modified_gmt":"2018-12-03 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