{"id":24295,"date":"2015-09-01T00:00:00","date_gmt":"2018-12-03T20:50:31","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/anticholinesterases-and-antioxidant-alkamides-from-piper\/"},"modified":"2018-12-03T21:50:31","modified_gmt":"2018-12-03T20:50:31","slug":"anticholinesterases-and-antioxidant-alkamides-from-piper","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/anticholinesterases-and-antioxidant-alkamides-from-piper\/","title":{"rendered":"Anticholinesterases and antioxidant alkamides from Piper nigrum fruits."},"content":{"rendered":"<p style=\"text-align:justify\">The anticholinesterase and antioxidant effects of five different extracts of Piper nigrum were evaluated. Twenty-one known alkamides were isolated from active ethyl acetate extract and investigated for their cholinesterase inhibitory and antioxidant effects. Among them, piperine (2), piperettine (5) and piperettyline (20) exhibited dual inhibition against AChE and BChE, and feruperine (18) was the most potent selective inhibitor of BChE. Molecular docking simulation was performed to get insight into the binding interactions of the ligands and enzymes. In addition, N-trans-feruloyltyramine (3) contributed to the strongest DPPH radical-scavenging activity. The self-induced A&Icirc;&sup2; aggregation inhibition of 2, 5 and 18 was further evaluated. Results indicated that some alkamides could be multifunctional lead candidates for Alzheimer&#039;s disease therapy.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-24295","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"School of Chemical Engineering , Sichuan University , Chengdu , China.","annee":"2015","mois":"9","numero":"","page":"","auteurs":[{"ID":13452,"post_author":"0","post_date":"2018-12-03 18:58:20","post_date_gmt":"2018-12-03 17:58:20","post_content":"","post_title":"Wei-Ping Luo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"wei-ping-luo","to_ping":"","pinged":"","post_modified":"2018-12-03 18:58:20","post_modified_gmt":"2018-12-03 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Zhong","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yujiao-zhong","to_ping":"","pinged":"","post_modified":"2018-12-03 21:50:26","post_modified_gmt":"2018-12-03 20:50:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/yujiao-zhong\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":24292,"post_author":"0","post_date":"2018-12-03 21:50:27","post_date_gmt":"2018-12-03 20:50:27","post_content":"","post_title":"Hongjian Du","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"hongjian-du","to_ping":"","pinged":"","post_modified":"2018-12-03 21:50:27","post_modified_gmt":"2018-12-03 20:50:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/hongjian-du\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":24293,"post_author":"0","post_date":"2018-12-03 21:50:28","post_date_gmt":"2018-12-03 20:50:28","post_content":"","post_title":"Yaya Wen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yaya-wen","to_ping":"","pinged":"","post_modified":"2018-12-03 21:50:28","post_modified_gmt":"2018-12-03 20:50:28","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/yaya-wen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9867,"post_author":"0","post_date":"2018-12-03 18:16:01","post_date_gmt":"2018-12-03 17:16:01","post_content":"","post_title":"Qing Liu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"qing-liu","to_ping":"","pinged":"","post_modified":"2018-12-03 18:16:01","post_modified_gmt":"2018-12-03 17:16:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/qing-liu\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":24294,"post_author":"0","post_date":"2018-12-03 21:50:30","post_date_gmt":"2018-12-03 20:50:30","post_content":"","post_title":"Chao Zhu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"chao-zhu","to_ping":"","pinged":"","post_modified":"2018-12-03 21:50:30","post_modified_gmt":"2018-12-03 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research","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"natural-product-research","to_ping":"","pinged":"","post_modified":"2018-12-03 17:42:24","post_modified_gmt":"2018-12-03 16:42:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/natural-product-research\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Anticholinesterases and antioxidant alkamides from Piper nigrum fruits. - Aprifel<\/title>\n<meta name=\"description\" content=\"Anticholinesterases and antioxidant alkamides from Piper nigrum fruits. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" 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