{"id":23790,"date":"2015-10-01T00:00:00","date_gmt":"2018-12-03T20:36:38","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-insulin-resistance-phenotype-muscle-or-liver-interacts\/"},"modified":"2018-12-03T21:36:38","modified_gmt":"2018-12-03T20:36:38","slug":"the-insulin-resistance-phenotype-muscle-or-liver-interacts","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-insulin-resistance-phenotype-muscle-or-liver-interacts\/","title":{"rendered":"The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2&Acirc;&nbsp;years of intervention: the CORDIOPREV-DIAB randomised clinical trial."},"content":{"rendered":"<p style=\"text-align: justify\"><strong>AIMS \/ HYPOTHESIS:<\/strong><\/p>\n<p style=\"text-align: justify\">The aim of the study was to determine whether basal insulin resistance (IR) phenotype (muscle and\/or liver) determines the effect of long-term consumption of a Mediterranean diet or a low-fat diet on tissue-specific IR and beta cell function.<\/p>\n<p style=\"text-align: justify\"><strong>METHODS:<\/strong><\/p>\n<p style=\"text-align: justify\">The study was performed in 642 patients included in The effect of an olive oil rich Mediterranean diet on type 2 diabetes mellitus risk and incidence study (CORDIOPREV-DIAB). A total of 327 patients were randomised to a Mediterranean diet (35% fat; 22% from monounsaturated fatty acids) and 315 to a low-fat diet (&lt;28% fat). At baseline, the patients were classified into four phenotypes according to the type of IR: (1) no IR; (2) muscle IR; (3) liver IR; (4) muscle&thinsp;+&thinsp;liver IR. The hepatic insulin resistance index (HIRI), muscular insulin sensitivity index (MISI) and disposition index were analysed at baseline and after 2&nbsp;years of follow-up.<\/p>\n<p style=\"text-align: justify\"><strong>RESULTS:<\/strong><\/p>\n<p style=\"text-align: justify\">At baseline, 322 patients presented no IR, 106 presented muscle IR, 109 presented liver IR, and 105 presented muscle&thinsp;+&thinsp;liver IR. With both dietary interventions, HIRI decreased in all patients (p&thinsp;&lt;&thinsp;0.001) and MISI increased in muscle IR and muscle&thinsp;+&thinsp;liver IR patients (p&thinsp;&lt;&thinsp;0.01). Long-term intake of the Mediterranean diet increased the disposition index and insulinogenic index in the muscle IR patients (p&thinsp;=&thinsp;0.042 and p&thinsp;=&thinsp;0.044, respectively) and the disposition index in the muscle&thinsp;+&thinsp;liver IR patients (p&thinsp;=&thinsp;0.048), whereas the low-fat diet increased the disposition index in the liver IR patients (p&thinsp;=&thinsp;0.017).<\/p>\n<p style=\"text-align: justify\"><strong>CONCLUSIONS \/ INTERPRETATION:<\/strong><\/p>\n<p style=\"text-align: justify\">Although both diets improve insulin sensitivity, there are differences based on basal IR phenotypes. Moreover, according to insulinogenic and disposition index data, a low-fat diet might be more beneficial to patients with liver IR, whereas patients with muscle IR and muscle&thinsp;+&thinsp;liver IR might benefit more from a Mediterranean diet.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-23790","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, Avda Menendez Pidal, s\/n, 14004, Cordoba, Spain.\r\njlopezmir@uco.es","annee":"2015","mois":"10","numero":":","page":"","auteurs":[{"ID":7532,"post_author":"0","post_date":"2018-12-03 17:50:13","post_date_gmt":"2018-12-03 16:50:13","post_content":"","post_title":"Jose M Ordovas","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jose-m-ordovas","to_ping":"","pinged":"","post_modified":"2018-12-03 17:50:13","post_modified_gmt":"2018-12-03 16:50:13","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jose-m-ordovas\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9285,"post_author":"0","post_date":"2018-12-03 18:09:27","post_date_gmt":"2018-12-03 17:09:27","post_content":"","post_title":"Javier Delgado-Lista","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"javier-delgado-lista","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:27","post_modified_gmt":"2018-12-03 17:09:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/javier-delgado-lista\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9286,"post_author":"0","post_date":"2018-12-03 18:09:27","post_date_gmt":"2018-12-03 17:09:27","post_content":"","post_title":"Pablo Perez-Martinez","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pablo-perez-martinez","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:27","post_modified_gmt":"2018-12-03 17:09:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pablo-perez-martinez\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9287,"post_author":"0","post_date":"2018-12-03 18:09:28","post_date_gmt":"2018-12-03 17:09:28","post_content":"","post_title":"Francisco Perez-Jimenez","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"francisco-perez-jimenez","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:28","post_modified_gmt":"2018-12-03 17:09:28","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/francisco-perez-jimenez\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4542,"post_author":"0","post_date":"2018-12-03 17:18:29","post_date_gmt":"2018-12-03 16:18:29","post_content":"","post_title":"Jose Lopez-Miranda","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jose-lopez-miranda","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:29","post_modified_gmt":"2018-12-03 16:18:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jose-lopez-miranda\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23789,"post_author":"0","post_date":"2018-12-03 21:36:36","post_date_gmt":"2018-12-03 20:36:36","post_content":"","post_title":"Ruth Blanco-Rojo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ruth-blanco-rojo","to_ping":"","pinged":"","post_modified":"2018-12-03 21:36:36","post_modified_gmt":"2018-12-03 20:36:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ruth-blanco-rojo\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10869,"post_author":"0","post_date":"2018-12-03 18:28:29","post_date_gmt":"2018-12-03 17:28:29","post_content":"","post_title":"Juan F Alcala-Diaz","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"juan-f-alcala-diaz","to_ping":"","pinged":"","post_modified":"2018-12-03 18:28:29","post_modified_gmt":"2018-12-03 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Quintana-Navarro","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gracia-m-quintana-navarro","to_ping":"","pinged":"","post_modified":"2018-12-03 21:25:48","post_modified_gmt":"2018-12-03 20:25:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/gracia-m-quintana-navarro\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17620,"post_author":"0","post_date":"2018-12-03 19:54:34","post_date_gmt":"2018-12-03 18:54:34","post_content":"","post_title":"Carmen Santamari\u00f1a","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"carmen-santamarina","to_ping":"","pinged":"","post_modified":"2018-12-03 19:54:34","post_modified_gmt":"2018-12-03 18:54:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/carmen-santamarina\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9290,"post_author":"0","post_date":"2018-12-03 18:09:29","post_date_gmt":"2018-12-03 17:09:29","post_content":"","post_title":"Ben van Ommen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ben-van-ommen","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:29","post_modified_gmt":"2018-12-03 17:09:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ben-van-ommen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1351,"post_author":"0","post_date":"2018-12-03 15:58:34","post_date_gmt":"2018-12-03 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