{"id":23419,"date":"2015-10-01T00:00:00","date_gmt":"2018-12-03T20:25:53","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/two-healthy-diets-modulate-gut-microbial-community-improving\/"},"modified":"2018-12-03T21:25:53","modified_gmt":"2018-12-03T20:25:53","slug":"two-healthy-diets-modulate-gut-microbial-community-improving","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/two-healthy-diets-modulate-gut-microbial-community-improving\/","title":{"rendered":"Two healthy diets modulate gut microbial community improving insulin sensitivity in a human obese population."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>CONTEXT<\/strong><br \/>\nGut microbiota, which acts collectively as a fully-integrated organ in the host metabolism, can be shaped by long-term dietary interventions following a specific diet.<\/p>\n<p style=\"text-align:justify\"><strong>OBJECTIVE<\/strong><br \/>\nTo study the changes in microbiota after one year&#039;s consumption of a Mediterranean diet (Med diet) or a low-fat, high-complex carbohydrates diet (LFHCC diet) in an obese population.<\/p>\n<p style=\"text-align:justify\"><strong>DESIGN<\/strong><br \/>\nParticipant swere randomized to receive Med diet (35% fat, 22% monounsaturated) and LFHCC diet (28% fat, 12% monounsaturated).<\/p>\n<p style=\"text-align:justify\"><strong>SETTING AND PARTICIPANTS<\/strong><br \/>\nThe study was conducted in 20 obese patients (men) within the CORDIOPREV study, an ongoing prospective, randomized, opened, controlled trial in patients with coronary heart disease.<\/p>\n<p style=\"text-align:justify\"><strong>MAIN OUTCOME MEASURE<\/strong><br \/>\nWe evaluated the bacterial composition and its relationship with the whole fecal and plasma metabolome.<\/p>\n<p style=\"text-align:justify\"><strong>RESULTS<\/strong><br \/>\nThe LFHCC diet increased Prevotella and decreased the Roseburia genera while the Med diet decreased Prevotella and increased the Roseburia and Oscillospira genera (P=0.028, 0.002, and 0.016, respectively). The abundance of Parabacteroides distasonis (P=0.025) and Faecalibactrium prausnitzii (P=0.020) increased after the long-term consumption of the Med diet and LFHCC diet, respectively. The changes in the abundance of 7 out of 572 metabolites found in feces, including mainly aminoacids, peptides and the sphingolipid metabolism, could be linked to the changes in the gut microbiota.<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSIONS<\/strong><br \/>\nOur results suggest that a long-term consumption of the Med and LFHCC diets, exert a protective effect on the development of type 2 diabetes by different specific changes in the gut microbiota, increasing the abundance of the Roseburia genus and Faecalibacterium prausnitzii, respectively.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-23419","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Lipids and Atherosclerosis Unit, GC9 Nutrigenomics. 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Quintana-Navarro","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gracia-m-quintana-navarro","to_ping":"","pinged":"","post_modified":"2018-12-03 21:25:48","post_modified_gmt":"2018-12-03 20:25:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/gracia-m-quintana-navarro\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10870,"post_author":"0","post_date":"2018-12-03 18:28:30","post_date_gmt":"2018-12-03 17:28:30","post_content":"","post_title":"Carmen Haro","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"carmen-haro","to_ping":"","pinged":"","post_modified":"2018-12-03 18:28:30","post_modified_gmt":"2018-12-03 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Rangel-Z\u00fa\u00f1iga","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"oriol-a-rangel-zuniga","to_ping":"","pinged":"","post_modified":"2018-12-03 18:28:32","post_modified_gmt":"2018-12-03 17:28:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/oriol-a-rangel-zuniga\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23417,"post_author":"0","post_date":"2018-12-03 21:25:51","post_date_gmt":"2018-12-03 20:25:51","post_content":"","post_title":"Francisco G\u00f3mez-Delgado","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"francisco-gomez-delgado","to_ping":"","pinged":"","post_modified":"2018-12-03 21:25:51","post_modified_gmt":"2018-12-03 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17:09:30","post_content":"","post_title":"Francisco J Tinahones","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"francisco-j-tinahones","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:30","post_modified_gmt":"2018-12-03 17:09:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/francisco-j-tinahones\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10871,"post_author":"0","post_date":"2018-12-03 18:28:30","post_date_gmt":"2018-12-03 17:28:30","post_content":"","post_title":"Blanca B Landa","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"blanca-b-landa","to_ping":"","pinged":"","post_modified":"2018-12-03 18:28:30","post_modified_gmt":"2018-12-03 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Camargo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"antonio-camargo","to_ping":"","pinged":"","post_modified":"2018-12-03 18:28:31","post_modified_gmt":"2018-12-03 17:28:31","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/antonio-camargo\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9287,"post_author":"0","post_date":"2018-12-03 18:09:28","post_date_gmt":"2018-12-03 17:09:28","post_content":"","post_title":"Francisco Perez-Jimenez","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"francisco-perez-jimenez","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:28","post_modified_gmt":"2018-12-03 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