{"id":23343,"date":"2015-11-01T00:00:00","date_gmt":"2018-12-03T20:24:09","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/defining-key-structural-determinants-for-the-pro-osteogenic\/"},"modified":"2018-12-03T21:24:09","modified_gmt":"2018-12-03T20:24:09","slug":"defining-key-structural-determinants-for-the-pro-osteogenic","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/defining-key-structural-determinants-for-the-pro-osteogenic\/","title":{"rendered":"Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids."},"content":{"rendered":"<p style=\"text-align:justify\">Epidemiological studies suggest that fruits and vegetables may play a role in promoting bone growth and preventing age-related bone loss, attributable, at least in part, to phytochemicals such as flavonoids stimulating osteoblastogenesis. Through systematically screening the effect of flavonoids on the osteogenic differentiation of human mesenchymal stem cells in vitro and correlating activity with chemical structure using comparative molecular field analysis, we have successfully identified important structural features that relate to their activity, as well as reliably predicted the activity of compounds with unknown activity. Contour maps emphasized the importance of electronegativity, steric bulk, and a 2-C-3-C double bond at the flavonoid C-ring, as well as overall electropositivity and reduced steric bulk at the flavonoid B-ring. These results support a role for certain flavonoids in promoting osteogenic differentiation, thus their potential for preventing skeletal deterioration, as well as providing a foundation for the lead optimization of novel bone anabolics.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-23343","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Reading School of Pharmacy, University of Reading , Whiteknights, Reading RG6 6UB, UK.\r\nk.bicknell@reading.ac.uk","annee":"2015","mois":"11","numero":"78:11","page":"2598-608","auteurs":[{"ID":23336,"post_author":"0","post_date":"2018-12-03 21:24:02","post_date_gmt":"2018-12-03 20:24:02","post_content":"","post_title":"Stephen Swioklo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"stephen-swioklo","to_ping":"","pinged":"","post_modified":"2018-12-03 21:24:02","post_modified_gmt":"2018-12-03 20:24:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/stephen-swioklo\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23337,"post_author":"0","post_date":"2018-12-03 21:24:03","post_date_gmt":"2018-12-03 20:24:03","post_content":"","post_title":"Kimberly A Watson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kimberly-a-watson","to_ping":"","pinged":"","post_modified":"2018-12-03 21:24:03","post_modified_gmt":"2018-12-03 20:24:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/kimberly-a-watson\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23338,"post_author":"0","post_date":"2018-12-03 21:24:04","post_date_gmt":"2018-12-03 20:24:04","post_content":"","post_title":"Elizabeth M Williamson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"elizabeth-m-williamson","to_ping":"","pinged":"","post_modified":"2018-12-03 21:24:04","post_modified_gmt":"2018-12-03 20:24:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/elizabeth-m-williamson\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23339,"post_author":"0","post_date":"2018-12-03 21:24:05","post_date_gmt":"2018-12-03 20:24:05","post_content":"","post_title":"Jonathan A Farrimond","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jonathan-a-farrimond","to_ping":"","pinged":"","post_modified":"2018-12-03 21:24:05","post_modified_gmt":"2018-12-03 20:24:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jonathan-a-farrimond\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23340,"post_author":"0","post_date":"2018-12-03 21:24:06","post_date_gmt":"2018-12-03 20:24:06","post_content":"","post_title":"Sophie E Putnam","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"sophie-e-putnam","to_ping":"","pinged":"","post_modified":"2018-12-03 21:24:06","post_modified_gmt":"2018-12-03 20:24:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/sophie-e-putnam\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23341,"post_author":"0","post_date":"2018-12-03 21:24:07","post_date_gmt":"2018-12-03 20:24:07","post_content":"","post_title":"Katrina A Bicknell","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"katrina-a-bicknell","to_ping":"","pinged":"","post_modified":"2018-12-03 21:24:07","post_modified_gmt":"2018-12-03 20:24:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/katrina-a-bicknell\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":23342,"post_author":"0","post_date":"2018-12-03 21:24:09","post_date_gmt":"2018-12-03 20:24:09","post_content":"","post_title":"Journal of natural products","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"journal-of-natural-products","to_ping":"","pinged":"","post_modified":"2018-12-03 21:24:09","post_modified_gmt":"2018-12-03 20:24:09","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/journal-of-natural-products\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. - Aprifel<\/title>\n<meta name=\"description\" content=\"Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids.\" \/>\n<meta property=\"og:description\" content=\"Defining Key Structural 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