{"id":22650,"date":"2015-12-01T00:00:00","date_gmt":"2018-12-03T20:09:14","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-joint-effects-of-lifestyle-factors-and-comorbidities-on\/"},"modified":"2018-12-03T21:09:14","modified_gmt":"2018-12-03T20:09:14","slug":"the-joint-effects-of-lifestyle-factors-and-comorbidities-on","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-joint-effects-of-lifestyle-factors-and-comorbidities-on\/","title":{"rendered":"The Joint Effects of Lifestyle Factors and Comorbidities on the Risk of Colorectal Cancer: A Large Chinese Retrospective Case-Control Study."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>BACKGROUND<\/strong><br \/>\nColorectal cancer (CRC) is a major cause of cancer morbidity and mortality. In previous epidemiologic studies, the respective correlation between lifestyle factors and comorbidity and CRC has been extensively studied. However, little is known about their joint effects on CRC.<\/p>\n<p style=\"text-align:justify\"><strong>METHODS<\/strong><br \/>\nWe conducted a retrospective case-control study of 1,144 diagnosed CRC patients and 60,549 community controls. A structured questionnaire was administered to the participants about their socio-demographic factors, anthropometric measures, comorbidity history and lifestyle factors. Logistic regression model was used to calculate the odds ratio (ORs) and 95% confidence intervals (95%CIs) for each factor. According to the results from logistic regression model, we further developed healthy lifestyle index (HLI) and comorbidity history index (CHI) to investigate their independent and joint effects on CRC risk.<\/p>\n<p style=\"text-align:justify\"><strong>RESULTS<\/strong><br \/>\nFour lifestyle factors (including physical activities, sleep, red meat and vegetable consumption) and four types of comorbidity (including diabetes, hyperlipidemia, history of inflammatory bowel disease and polyps) were found to be independently associated with the risk of CRC in multivariant logistic regression model. Intriguingly, their combined pattern- HLI and CHI demonstrated significant correlation with CRC risk independently (ORHLI: 3.91, 95%CI: 3.13-4.88; ORCHI: 2.49, 95%CI: 2.11-2.93) and jointly (OR: 10.33, 95%CI: 6.59-16.18).<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSIONS<\/strong><br \/>\nThere are synergistic effects of lifestyle factors and comorbidity on the risk of colorectal cancer in the Chinese population.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-22650","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Oncology and Pancreatic Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.","annee":"2015","mois":"12","numero":"10:12","page":"e0143696","auteurs":[{"ID":22639,"post_author":"0","post_date":"2018-12-03 21:09:02","post_date_gmt":"2018-12-03 20:09:02","post_content":"","post_title":"Junjie Hang","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"junjie-hang","to_ping":"","pinged":"","post_modified":"2018-12-03 21:09:02","post_modified_gmt":"2018-12-03 20:09:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/junjie-hang\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":22640,"post_author":"0","post_date":"2018-12-03 21:09:03","post_date_gmt":"2018-12-03 20:09:03","post_content":"","post_title":"Binxin Cai","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"binxin-cai","to_ping":"","pinged":"","post_modified":"2018-12-03 21:09:03","post_modified_gmt":"2018-12-03 20:09:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/binxin-cai\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":22641,"post_author":"0","post_date":"2018-12-03 21:09:04","post_date_gmt":"2018-12-03 20:09:04","post_content":"","post_title":"Peng Xue","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"peng-xue","to_ping":"","pinged":"","post_modified":"2018-12-03 21:09:04","post_modified_gmt":"2018-12-03 20:09:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/peng-xue\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":22642,"post_author":"0","post_date":"2018-12-03 21:09:06","post_date_gmt":"2018-12-03 20:09:06","post_content":"","post_title":"Lei Wang","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lei-wang","to_ping":"","pinged":"","post_modified":"2018-12-03 21:09:06","post_modified_gmt":"2018-12-03 20:09:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/lei-wang\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":20029,"post_author":"0","post_date":"2018-12-03 20:29:31","post_date_gmt":"2018-12-03 19:29:31","post_content":"","post_title":"Hai Ngoc Phung","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"hai-ngoc-phung","to_ping":"","pinged":"","post_modified":"2018-12-03 20:29:31","post_modified_gmt":"2018-12-03 19:29:31","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/hai-ngoc-phung\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":22643,"post_author":"0","post_date":"2018-12-03 21:09:07","post_date_gmt":"2018-12-03 20:09:07","post_content":"","post_title":"Yangyang Zhou","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yangyang-zhou","to_ping":"","pinged":"","post_modified":"2018-12-03 21:09:07","post_modified_gmt":"2018-12-03 20:09:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/yangyang-zhou\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":22644,"post_author":"0","post_date":"2018-12-03 21:09:08","post_date_gmt":"2018-12-03 20:09:08","post_content":"","post_title":"Shujuan Ren","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"shujuan-ren","to_ping":"","pinged":"","post_modified":"2018-12-03 21:09:08","post_modified_gmt":"2018-12-03 20:09:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/shujuan-ren\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":22645,"post_author":"0","post_date":"2018-12-03 21:09:09","post_date_gmt":"2018-12-03 20:09:09","post_content":"","post_title":"Jiajin Wu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jiajin-wu","to_ping":"","pinged":"","post_modified":"2018-12-03 21:09:09","post_modified_gmt":"2018-12-03 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Chen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"donghui-chen","to_ping":"","pinged":"","post_modified":"2018-12-03 21:09:11","post_modified_gmt":"2018-12-03 20:09:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/donghui-chen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":22648,"post_author":"0","post_date":"2018-12-03 21:09:12","post_date_gmt":"2018-12-03 20:09:12","post_content":"","post_title":"Haiyan Yang","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"haiyan-yang","to_ping":"","pinged":"","post_modified":"2018-12-03 21:09:12","post_modified_gmt":"2018-12-03 20:09:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/haiyan-yang\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":22649,"post_author":"0","post_date":"2018-12-03 21:09:13","post_date_gmt":"2018-12-03 20:09:13","post_content":"","post_title":"Liwei Wang","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"liwei-wang","to_ping":"","pinged":"","post_modified":"2018-12-03 21:09:13","post_modified_gmt":"2018-12-03 20:09:13","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/liwei-wang\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1142,"post_author":"0","post_date":"2018-12-03 15:56:43","post_date_gmt":"2018-12-03 14:56:43","post_content":"","post_title":"PloS 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