{"id":22401,"date":"2016-01-01T00:00:00","date_gmt":"2018-12-03T20:03:56","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/association-of-dietary-nitrate-intake-with-primary-open-angle\/"},"modified":"2018-12-03T21:03:56","modified_gmt":"2018-12-03T20:03:56","slug":"association-of-dietary-nitrate-intake-with-primary-open-angle","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/association-of-dietary-nitrate-intake-with-primary-open-angle\/","title":{"rendered":"Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma: A Prospective Analysis From the Nurses’ Health Study and Health Professionals Follow-up Study."},"content":{"rendered":"

Importance<\/strong>
\nNitric oxide signaling alterations in outflow facility and retinal blood flow autoregulation are implicated in primary open-angle glaucoma (POAG). Nitric oxide donation has emerged as a POAG therapeutic target. An exogenous source of nitric oxide is dietary nitrates.<\/p>\n

Objective<\/strong>
\nTo evaluate the association between dietary nitrate intake, derived mainly from green leafy vegetables, and POAG.<\/p>\n

Design, Setting, and Participants<\/strong>
\nWe followed up participants biennially in the prospective cohorts of the Nurses' Health Study (63\u202f893 women; 1984-2012) and the Health Professionals Follow-up Study (41\u202f094 men; 1986-2012) at each 2-year risk period. Eligible participants were 40 years or older, were free of POAG, and reported eye examinations.<\/p>\n

Exposures<\/strong>
\nThe primary exposure was dietary nitrate intake. Information on diet and potential confounders was updated with validated questionnaires.<\/p>\n

Main Outcomes and Measures<\/strong>
\nThe main outcome was the incidence of POAG and POAG subtypes; 1483 cases were confirmed with medical records and classified into subtypes defined by intraocular pressure (IOP) (≥22 or <22 mm Hg) or by visual field (VF) loss pattern at diagnosis (peripheral loss only or early paracentral loss). Cohort-specific and pooled multivariable rate ratios (MVRRs) and 95% CIs were estimated.<\/p>\n

Results<\/strong>
\nDuring 1\u202f678\u202f713 person-years of follow-up, 1483 incident cases of POAG were identified. The mean (SD) age for the 1483 cases was 66.8 (8.3). Compared with the lowest quintile of dietary nitrate intake (quintile 1: approximately 80 mg\/d), the pooled MVRR for the highest quintile (quintile 5: approximately 240 mg\/d) was 0.79 (95% CI, 0.66-0.93; P for trend = .02). The dose response was stronger (P for heterogeneity = .01) for POAG with early paracentral VF loss (433 cases; quintile 5 vs quintile 1 MVRR = 0.56; 95% CI, 0.40-0.79; P for trend < .001) than for POAG with peripheral VF loss only (835 cases; quintile 5 vs quintile 1 MVRR = 0.85; 95% CI, 0.68-1.06; P for trend = .50). The association did not differ (P for heterogeneity = .75) by POAG subtypes defined by IOP (997 case patients with IOP ≥22 mm Hg: quintile 5 vs quintile 1 MVRR = 0.82; 95% CI, 0.67-1.01; P for trend = .11; 486 case patients with IOP <22 mm Hg: quintile 5 vs quintile 1 MVRR = 0.71; 95% CI, 0.53-0.96; P for trend = .12). Green leafy vegetables accounted for 56.7% of nitrate intake variation. Compared with consuming 0.31 servings per day, the MVRR for consuming 1.45 or more servings per day was 0.82 for all POAG (95% CI, 0.69-0.97; P for trend = .02) and 0.52 for POAG with paracentral VF loss (95% CI, 0.29-0.96; P for trend < .001).<\/p>\n

Conclusions and Relevance<\/strong>
\nHigher dietary nitrate and green leafy vegetable intake was associated with a lower POAG risk, particularly POAG with early paracentral VF loss at diagnosis.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-22401","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts.","annee":"2016","mois":"1","numero":"","page":"","auteurs":[{"ID":1412,"post_author":"0","post_date":"2018-12-03 15:59:08","post_date_gmt":"2018-12-03 14:59:08","post_content":"","post_title":"Walter C Willett","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"walter-c-willett","to_ping":"","pinged":"","post_modified":"2018-12-03 15:59:08","post_modified_gmt":"2018-12-03 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Kang","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jae-heon-kang","to_ping":"","pinged":"","post_modified":"2018-12-03 21:03:54","post_modified_gmt":"2018-12-03 20:03:54","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jae-heon-kang\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":22399,"post_author":"0","post_date":"2018-12-03 21:03:55","post_date_gmt":"2018-12-03 20:03:55","post_content":"","post_title":"Emmanuel Buys","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"emmanuel-buys","to_ping":"","pinged":"","post_modified":"2018-12-03 21:03:55","post_modified_gmt":"2018-12-03 20:03:55","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/emmanuel-buys\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18861,"post_author":"0","post_date":"2018-12-03 20:13:41","post_date_gmt":"2018-12-03 19:13:41","post_content":"","post_title":"Janey L Wiggs","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"janey-l-wiggs","to_ping":"","pinged":"","post_modified":"2018-12-03 20:13:41","post_modified_gmt":"2018-12-03 19:13:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/janey-l-wiggs\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18862,"post_author":"0","post_date":"2018-12-03 20:13:42","post_date_gmt":"2018-12-03 19:13:42","post_content":"","post_title":"Louis R Pasquale","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"louis-r-pasquale","to_ping":"","pinged":"","post_modified":"2018-12-03 20:13:42","post_modified_gmt":"2018-12-03 19:13:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/louis-r-pasquale\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":22400,"post_author":"0","post_date":"2018-12-03 21:03:56","post_date_gmt":"2018-12-03 20:03:56","post_content":"","post_title":"JAMA ophthalmology","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jama-ophthalmology","to_ping":"","pinged":"","post_modified":"2018-12-03 21:03:56","post_modified_gmt":"2018-12-03 20:03:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/jama-ophthalmology\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nAssociation of Dietary Nitrate Intake With Primary Open-Angle Glaucoma: A Prospective Analysis From the Nurses' Health Study and Health Professionals Follow-up Study. - Aprifel<\/title>\n<meta name=\"description\" content=\"Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma: A Prospective Analysis From the Nurses' Health Study and Health Professionals Follow-up Study. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma: A Prospective Analysis From the Nurses' Health Study and Health Professionals 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