{"id":21317,"date":"2016-04-01T00:00:00","date_gmt":"2018-12-03T19:48:11","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/concentrations-of-thiocyanate-and-goitrin-in-human-plasma\/"},"modified":"2018-12-03T20:48:11","modified_gmt":"2018-12-03T19:48:11","slug":"concentrations-of-thiocyanate-and-goitrin-in-human-plasma","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/concentrations-of-thiocyanate-and-goitrin-in-human-plasma\/","title":{"rendered":"Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism."},"content":{"rendered":"<p style=\"text-align:justify\">Brassica vegetables are common components of the diet and have beneficial as well as potentially adverse health effects. Following enzymatic breakdown, some glucosinolates in brassica vegetables produce sulforaphane, phenethyl, and indolylic isothiocyanates that possess anticarcinogenic activity. In contrast, progoitrin and indolylic glucosinolates degrade to goitrin and thiocyanate, respectively, and may decrease thyroid hormone production. Radioiodine uptake to the thyroid is inhibited by 194&thinsp;&mu;mol of goitrin, but not by 77&thinsp;&mu;mol of goitrin. Collards, Brussels sprouts, and some Russian kale (Brassica napus) contain sufficient goitrin to potentially decrease iodine uptake by the thyroid. However, turnip tops, commercial broccoli, broccoli rabe, and kale belonging to Brassica oleracae contain less than 10&thinsp;&mu;mol of goitrin per 100-g serving and can be considered of minimal risk. Using sulforaphane plasma levels following glucoraphanin ingestion as a surrogate for thiocyanate plasma concentrations after indole glucosinolate ingestion, the maximum thiocyanate contribution from indole glucosinolate degradation is estimated to be 10&thinsp;&mu;M, which is significantly lower than background plasma thiocyanate concentrations (40-69&thinsp;&mu;M). Thiocyanate generated from consumption of indole glucosinolate can be assumed to have minimal adverse risks for thyroid health.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-21317","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"P. Felker and R. Bunch are with the D'Arrigo Bros. Co., of California, Salinas, California, USA. A.M. Leung is with the Division of Endocrinology, VA Greater Los Angeles Healthcare System, Los Angeles, California, and the Division of Endocrinology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. Peter.Felker@darrigo.com.","annee":"2016","mois":"4","numero":"74:4","page":"248-58","auteurs":[{"ID":21314,"post_author":"0","post_date":"2018-12-03 20:48:09","post_date_gmt":"2018-12-03 19:48:09","post_content":"","post_title":"Peter Felker","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"peter-felker","to_ping":"","pinged":"","post_modified":"2018-12-03 20:48:09","post_modified_gmt":"2018-12-03 19:48:09","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/peter-felker\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":21315,"post_author":"0","post_date":"2018-12-03 20:48:10","post_date_gmt":"2018-12-03 19:48:10","post_content":"","post_title":"Ronald Bunch","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ronald-bunch","to_ping":"","pinged":"","post_modified":"2018-12-03 20:48:10","post_modified_gmt":"2018-12-03 19:48:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ronald-bunch\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":21316,"post_author":"0","post_date":"2018-12-03 20:48:10","post_date_gmt":"2018-12-03 19:48:10","post_content":"","post_title":"Angela M Leung","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"angela-m-leung","to_ping":"","pinged":"","post_modified":"2018-12-03 20:48:10","post_modified_gmt":"2018-12-03 19:48:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/angela-m-leung\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":2828,"post_author":"0","post_date":"2018-12-03 16:59:32","post_date_gmt":"2018-12-03 15:59:32","post_content":"","post_title":"Nutrition reviews","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nutrition-reviews","to_ping":"","pinged":"","post_modified":"2018-12-03 16:59:32","post_modified_gmt":"2018-12-03 15:59:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/nutrition-reviews\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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