{"id":19773,"date":"2016-06-01T00:00:00","date_gmt":"2018-12-03T19:25:57","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-a-high-fat-mediterranean-diet-on-bodyweight-and-waist\/"},"modified":"2018-12-03T20:25:57","modified_gmt":"2018-12-03T19:25:57","slug":"effect-of-a-high-fat-mediterranean-diet-on-bodyweight-and-waist","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-a-high-fat-mediterranean-diet-on-bodyweight-and-waist\/","title":{"rendered":"Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>BACKGROUND<\/strong><br \/>\nBecause of the high density of fat, high-fat diets are perceived as likely to lead to increased bodyweight, hence health-care providers are reluctant to recommend them to overweight or obese individuals. We assessed the long-term effects of ad libitum, high-fat, high-vegetable-fat Mediterranean diets on bodyweight and waist circumference in older people at risk of cardiovascular disease, most of whom were overweight or obese.<\/p>\n<p style=\"text-align:justify\"><strong>METHODS<\/strong><br \/>\nPREDIMED was a 5 year parallel-group, multicentre, randomised, controlled clinical trial done in primary care centres affiliated to 11 hospitals in Spain. 7447 asymptomatic men (aged 55-80 years) and women (aged 60-80 years) who had type 2 diabetes or three or more cardiovascular risk factors were randomly assigned (1:1:1) with a computer-generated number sequence to one of three interventions: Mediterranean diet supplemented with extra-virgin olive oil (n=2543); Mediterranean diet supplemented with nuts (n=2454); or a control diet (advice to reduce dietary fat; n=2450). Energy restriction was not advised, nor was physical activity promoted. In this analysis of the trial, we measured bodyweight and waist circumference at baseline and yearly for 5 years in the intention-to-treat population. The PREDIMED trial is registered with ISRCTN.com, number ISRCTN35739639.<\/p>\n<p style=\"text-align:justify\"><strong>FINDINGS<\/strong><br \/>\nAfter a median 4&middot;8 years (IQR 2&middot;8-5&middot;8) of follow-up, participants in all three groups had marginally reduced bodyweight and increased waist circumference. The adjusted difference in 5 year changes in bodyweight in the Mediterranean diet with olive oil group was -0&middot;43 kg (95% CI -0&middot;86 to -0&middot;01; p=0&middot;044) and in the nut group was -0&middot;08 kg (-0&middot;50 to 0&middot;35; p=0&middot;730), compared with the control group. The adjusted difference in 5 year changes in waist circumference was -0&middot;55 cm (-1&middot;16 to -0&middot;06; p=0&middot;048) in the Mediterranean diet with olive oil group and -0&middot;94 cm (-1&middot;60 to -0&middot;27; p=0&middot;006) in the nut group, compared with the control group.<\/p>\n<p style=\"text-align:justify\"><strong>INTERPRETATION<\/strong><br \/>\nA long-term intervention with an unrestricted-calorie, high-vegetable-fat Mediterranean diet was associated with decreases in bodyweight and less gain in central adiposity compared with a control diet. These results lend support to advice not restricting intake of healthy fats for bodyweight maintenance.<\/p>\n<p style=\"text-align:justify\"><strong>FUNDING<\/strong><br \/>\nSpanish Government, CIBERobn, Instituto de Salud Carlos III, Hojiblanca, Patrimonio Comunal Olivarero, California Walnut Commission, Borges SA, and Morella Nuts.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-19773","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatologia de la Obesidad y la Nutrici\u00f3n, Instituto de Salud Carlos III, Madrid, Spain; Hospital Clinic, Institut d'Investigacions Biom\u00e8diques August Pi Sunyer, University of Barcelona, Barcelona, Spain. Electronic address: restruch@clinic.ub.es","annee":"2016","mois":"6","numero":"4:8","page":"666-76","auteurs":[{"ID":13681,"post_author":"0","post_date":"2018-12-03 19:00:56","post_date_gmt":"2018-12-03 18:00:56","post_content":"","post_title":"Rosa Maria Lamuela-Ravent\u00f3s","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rosa-maria-lamuela-raventos","to_ping":"","pinged":"","post_modified":"2018-12-03 19:00:56","post_modified_gmt":"2018-12-03 18:00:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rosa-maria-lamuela-raventos\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1164,"post_author":"0","post_date":"2018-12-03 15:56:56","post_date_gmt":"2018-12-03 14:56:56","post_content":"","post_title":"Ram\u00f3n Estruch","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ramon-estruch","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:56","post_modified_gmt":"2018-12-03 14:56:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ramon-estruch\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1549,"post_author":"0","post_date":"2018-12-03 16:00:25","post_date_gmt":"2018-12-03 15:00:25","post_content":"","post_title":"Miguel Angel Mart\u00ednez-Gonz\u00e1lez","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"miguel-angel-martinez-gonzalez","to_ping":"","pinged":"","post_modified":"2018-12-03 16:00:25","post_modified_gmt":"2018-12-03 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