{"id":19280,"date":"2016-08-01T00:00:00","date_gmt":"2018-12-03T19:19:07","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/blood-concentrations-of-carotenoids-and-retinol-andalungacancer\/"},"modified":"2018-12-03T20:19:07","modified_gmt":"2018-12-03T19:19:07","slug":"blood-concentrations-of-carotenoids-and-retinol-andalungacancer","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/blood-concentrations-of-carotenoids-and-retinol-andalungacancer\/","title":{"rendered":"Blood concentrations of carotenoids and retinol and\u00a0lung\u00a0cancer risk: an update of the WCRF-AICR systematic review of published prospective studies."},"content":{"rendered":"<p style=\"text-align:justify\">Carotenoids and retinol are considered biomarkers of fruits and vegetables intake, and are of much interest because of their anti-inflammatory and antioxidant properties; however, there is inconsistent evidence regarding their protective effects against lung cancer. We conducted a meta-analysis of prospective studies of blood concentrations of carotenoids and retinol, and lung cancer risk. We identified relevant prospective studies published up to December 2014 by searching the PubMed and several other databases. We calculated summary estimates of lung cancer risk for the highest compared with lowest carotenoid and retinol concentrations and dose-response meta-analyses using random effects models. We used fractional polynomial models to assess potential nonlinear relationships. Seventeen prospective studies (18 publications) including 3603 cases and 458,434 participants were included in the meta-analysis. Blood concentrations of &alpha;-carotene, &beta;-carotene, total carotenoids, and retinol were significantly inversely associated with lung cancer risk or mortality. The summary relative risk were 0.66 (95% confidence interval [CI]: 0.55-0.80) per 5&nbsp;&mu;g\/100&nbsp;mL of &alpha;-carotene (studies [n]&nbsp;=&nbsp;5), 0.84 (95% CI: 0.76-0.94) per 20&nbsp;&mu;g\/100&nbsp;mL of &beta;-carotene (n&nbsp;=&nbsp;9), 0.66 (95% CI: 0.54-0.81) per 100&nbsp;&mu;g\/100&nbsp;mL of total carotenoids (n&nbsp;=&nbsp;4), and 0.81 (95% CI: 0.73-0.90) per 70&nbsp;&mu;g\/100&nbsp;mL of retinol (n&nbsp;=&nbsp;8). In stratified analysis by sex, the significant inverse associations for &beta;-carotene and retinol were observed only in men and not in women. Nonlinear associations were observed for &beta;-carotene, &beta;-cryptoxanthin, and lycopene, with stronger associations observed at lower concentrations. There were not enough data to conduct stratified analyses by smoking. In conclusion, higher blood concentrations of several carotenoids and retinol are associated with reduced lung cancer risk. Further studies in never and former smokers are needed to rule out confounding by smoking.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-19280","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom. l.abar@imperial.ac.uk","annee":"2016","mois":"8","numero":"5:8","page":"2069-83","auteurs":[{"ID":9017,"post_author":"0","post_date":"2018-12-03 18:06:26","post_date_gmt":"2018-12-03 17:06:26","post_content":"","post_title":"Teresa Norat","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"teresa-norat","to_ping":"","pinged":"","post_modified":"2018-12-03 18:06:26","post_modified_gmt":"2018-12-03 17:06:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/teresa-norat\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19274,"post_author":"0","post_date":"2018-12-03 20:19:03","post_date_gmt":"2018-12-03 19:19:03","post_content":"","post_title":"Snieguole Vingeliene","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"snieguole-vingeliene","to_ping":"","pinged":"","post_modified":"2018-12-03 20:19:03","post_modified_gmt":"2018-12-03 19:19:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/snieguole-vingeliene\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9018,"post_author":"0","post_date":"2018-12-03 18:06:27","post_date_gmt":"2018-12-03 17:06:27","post_content":"","post_title":"Dagfinn Aune","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dagfinn-aune","to_ping":"","pinged":"","post_modified":"2018-12-03 18:06:27","post_modified_gmt":"2018-12-03 17:06:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dagfinn-aune\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19275,"post_author":"0","post_date":"2018-12-03 20:19:04","post_date_gmt":"2018-12-03 19:19:04","post_content":"","post_title":"Leila Abar","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"leila-abar","to_ping":"","pinged":"","post_modified":"2018-12-03 20:19:04","post_modified_gmt":"2018-12-03 19:19:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/leila-abar\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4189,"post_author":"0","post_date":"2018-12-03 17:13:16","post_date_gmt":"2018-12-03 16:13:16","post_content":"","post_title":"Darren C Greenwood","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"darren-c-greenwood","to_ping":"","pinged":"","post_modified":"2018-12-03 17:13:16","post_modified_gmt":"2018-12-03 16:13:16","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/darren-c-greenwood\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19276,"post_author":"0","post_date":"2018-12-03 20:19:04","post_date_gmt":"2018-12-03 19:19:04","post_content":"","post_title":"Ana Rita Vieira","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ana-rita-vieira","to_ping":"","pinged":"","post_modified":"2018-12-03 20:19:04","post_modified_gmt":"2018-12-03 19:19:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ana-rita-vieira\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19277,"post_author":"0","post_date":"2018-12-03 20:19:05","post_date_gmt":"2018-12-03 19:19:05","post_content":"","post_title":"Christophe Stevens","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"christophe-stevens","to_ping":"","pinged":"","post_modified":"2018-12-03 20:19:05","post_modified_gmt":"2018-12-03 19:19:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/christophe-stevens\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19278,"post_author":"0","post_date":"2018-12-03 20:19:06","post_date_gmt":"2018-12-03 19:19:06","post_content":"","post_title":"Deborah A Navarro Rosenblatt","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"deborah-a-navarro-rosenblatt","to_ping":"","pinged":"","post_modified":"2018-12-03 20:19:06","post_modified_gmt":"2018-12-03 19:19:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/deborah-a-navarro-rosenblatt\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":19279,"post_author":"0","post_date":"2018-12-03 20:19:06","post_date_gmt":"2018-12-03 19:19:06","post_content":"","post_title":"Doris Chan","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"doris-chan","to_ping":"","pinged":"","post_modified":"2018-12-03 20:19:06","post_modified_gmt":"2018-12-03 19:19:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/doris-chan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":4168,"post_author":"0","post_date":"2018-12-03 17:13:04","post_date_gmt":"2018-12-03 16:13:04","post_content":"","post_title":"Cancer medicine","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-medicine","to_ping":"","pinged":"","post_modified":"2018-12-03 17:13:04","post_modified_gmt":"2018-12-03 16:13:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-medicine\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Blood concentrations of carotenoids and retinol and\u00a0lung\u00a0cancer risk: an update of the WCRF-AICR systematic review of published prospective studies. - Aprifel<\/title>\n<meta name=\"description\" content=\"Blood concentrations of carotenoids and retinol and\u00a0lung\u00a0cancer risk: an update of the WCRF-AICR systematic review of published prospective studies. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Blood concentrations of 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