{"id":18751,"date":"2016-07-01T00:00:00","date_gmt":"2018-12-03T19:12:20","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/higher-fruit-intake-is-related-to-tnf-i-hypomethylation-and\/"},"modified":"2018-12-03T20:12:20","modified_gmt":"2018-12-03T19:12:20","slug":"higher-fruit-intake-is-related-to-tnf-i-hypomethylation-and","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/higher-fruit-intake-is-related-to-tnf-i-hypomethylation-and\/","title":{"rendered":"Higher Fruit Intake Is Related to TNF-\u03b1 Hypomethylation and Better Glucose Tolerance in Healthy Subjects."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>BACKGROUND\/AIM<\/strong><br \/>\nThis study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-&alpha; (TNF-&alpha;) promoter and decreased risk of metabolic changes.<\/p>\n<p style=\"text-align:justify\"><strong>METHODS<\/strong><br \/>\nForty normal-weight young women were involved in this cross-sectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-&alpha; was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005).<\/p>\n<p style=\"text-align:justify\"><strong>RESULTS<\/strong><br \/>\nContradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = -0.460, p = 0.003) and TNF-&alpha; total methylation (r = -0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-&alpha; methylation. No other dietary pattern was related to TNF-&alpha; methylation. TNF-&alpha; total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = -0.324, p = 0.041) and TNF-&alpha; total methylation (r = -0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-&alpha; total methylation (r = -0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-&alpha; total methylation.<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSION<\/strong><br \/>\nA healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-&alpha; methylation.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-18751","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Clinical and Social Nutrition, Universidade Federal de Ouro Preto, Minas Gerais, Brazil.","annee":"2016","mois":"7","numero":"9:2-4","page":"95-105","auteurs":[{"ID":7876,"post_author":"0","post_date":"2018-12-03 17:53:51","post_date_gmt":"2018-12-03 16:53:51","post_content":"","post_title":"J Alfredo 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19:12:16","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/josefina-bressan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18745,"post_author":"0","post_date":"2018-12-03 20:12:17","post_date_gmt":"2018-12-03 19:12:17","post_content":"","post_title":"J\u00falia Cristina Cardoso Carraro","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"julia-cristina-cardoso-carraro","to_ping":"","pinged":"","post_modified":"2018-12-03 20:12:17","post_modified_gmt":"2018-12-03 19:12:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/julia-cristina-cardoso-carraro\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18746,"post_author":"0","post_date":"2018-12-03 20:12:17","post_date_gmt":"2018-12-03 19:12:17","post_content":"","post_title":"Helen Hermana Miranda Hermsdorff","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"helen-hermana-miranda-hermsdorff","to_ping":"","pinged":"","post_modified":"2018-12-03 20:12:17","post_modified_gmt":"2018-12-03 19:12:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/helen-hermana-miranda-hermsdorff\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18747,"post_author":"0","post_date":"2018-12-03 20:12:18","post_date_gmt":"2018-12-03 19:12:18","post_content":"","post_title":"Maria Luisa Mansego","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"maria-luisa-mansego","to_ping":"","pinged":"","post_modified":"2018-12-03 20:12:18","post_modified_gmt":"2018-12-03 19:12:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/maria-luisa-mansego\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18748,"post_author":"0","post_date":"2018-12-03 20:12:18","post_date_gmt":"2018-12-03 19:12:18","post_content":"","post_title":"Maria \u00c1ngeles Zulet","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"maria-angeles-zulet","to_ping":"","pinged":"","post_modified":"2018-12-03 20:12:18","post_modified_gmt":"2018-12-03 19:12:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/maria-angeles-zulet\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18749,"post_author":"0","post_date":"2018-12-03 20:12:19","post_date_gmt":"2018-12-03 19:12:19","post_content":"","post_title":"Ferm\u00edn I Milagro","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"fermin-i-milagro","to_ping":"","pinged":"","post_modified":"2018-12-03 20:12:19","post_modified_gmt":"2018-12-03 19:12:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/fermin-i-milagro\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":18750,"post_author":"0","post_date":"2018-12-03 20:12:20","post_date_gmt":"2018-12-03 19:12:20","post_content":"","post_title":"Journal of nutrigenetics and nutrigenomics","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"journal-of-nutrigenetics-and-nutrigenomics","to_ping":"","pinged":"","post_modified":"2018-12-03 20:12:20","post_modified_gmt":"2018-12-03 19:12:20","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/journal-of-nutrigenetics-and-nutrigenomics\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Higher Fruit Intake Is Related to TNF-\u03b1 Hypomethylation and Better Glucose Tolerance in Healthy Subjects. - Aprifel<\/title>\n<meta name=\"description\" content=\"Higher Fruit Intake Is Related to TNF-\u03b1 Hypomethylation and Better Glucose Tolerance in Healthy Subjects. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Higher Fruit Intake Is Related to TNF-\u03b1 Hypomethylation and Better Glucose Tolerance in 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