{"id":18486,"date":"2016-09-01T00:00:00","date_gmt":"2018-12-03T19:07:42","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/long-term-immunomodulatory-effects-of-a-mediterranean-diet\/"},"modified":"2018-12-03T20:07:42","modified_gmt":"2018-12-03T19:07:42","slug":"long-term-immunomodulatory-effects-of-a-mediterranean-diet","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/long-term-immunomodulatory-effects-of-a-mediterranean-diet\/","title":{"rendered":"Long-Term Immunomodulatory Effects of a Mediterranean Diet in Adults at High Risk of Cardiovascular Disease in the PREvenci\u00f3n con DIeta MEDiterr\u00e1nea Randomized Controlled Trial."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>BACKGROUND<\/strong><br \/>\nThe Mediterranean diet (MedDiet) has demonstrated short-term anti-inflammatory effects, but little is known about its long-term immunomodulatory properties.<\/p>\n<p style=\"text-align:justify\"><strong>OBJECTIVE<\/strong><br \/>\nOur goal was to assess the long-term effects of the MedDiet on inflammatory markers related to atherogenesis in adults at high risk of cardiovascular disease (CVD) compared with the effects of a low-fat diet (LFD).<\/p>\n<p style=\"text-align:justify\"><strong>METHODS<\/strong><br \/>\nWe randomly assigned 165 high-risk participants (one-half men; mean age: 66 y) without overt CVD to 1 of 3 diets: a MedDiet supplemented with extra-virgin olive oil, a MedDiet supplemented with nuts, or an LFD. Follow-up data were collected at 3 and 5 y. Repeated-measures ANOVA, adjusted for potential confounding variables, was used to evaluate changes in diet adherence, CVD risk factors, and inflammatory variables.<\/p>\n<p style=\"text-align:justify\"><strong>RESULTS<\/strong><br \/>\nThe 2 MedDiet groups achieved a high degree of adherence to the intervention, and the LFD group had reduced energy intake from fat by 13% by 5 y. Compared with baseline, at 3 and 5 y, both MedDiet groups had significant reductions of &ge;16% in plasma concentrations of high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor &alpha;, and monocyte chemoattractant protein 1 (P &le; 0.04), whereas there were no significant changes in the LFD group. The reductions in CD49d and CD40 expressions in T lymphocytes and monocytes at 3 y were &ge;16% greater in both MedDiet groups than were the changes in the LFD group (P &lt; 0.001) at 3 y. Compared with baseline, at 3 y, the MedDiet groups had increased HDL-cholesterol (&ge;8%) and decreased blood pressure (&gt;4%) and total cholesterol, LDL-cholesterol, and triglyceride (&ge;8%) concentrations. At 5 y, concentrations of glucose (13%) and glycated hemoglobin (8%) had increased with the LFD.<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSIONS<\/strong><br \/>\nThe MedDiet participants had lower cellular and plasma concentrations of inflammatory markers related to atherosclerosis at 3 and 5 y. This anti-inflammatory role of the MedDiet could explain in part the long-term cardioprotective effect of the MedDiet against CVD.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-18486","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Internal Medicine, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona, Spain; CIBEROBN Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III (Carlos III Health Institute), Madrid, Spain. esacane@clinic.ub.es\r\n","annee":"2016","mois":"9","numero":"146:9","page":"1684-93","auteurs":[{"ID":1164,"post_author":"0","post_date":"2018-12-03 15:56:56","post_date_gmt":"2018-12-03 14:56:56","post_content":"","post_title":"Ram\u00f3n Estruch","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ramon-estruch","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:56","post_modified_gmt":"2018-12-03 14:56:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ramon-estruch\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4533,"post_author":"0","post_date":"2018-12-03 17:18:24","post_date_gmt":"2018-12-03 16:18:24","post_content":"","post_title":"Dolores Corella","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dolores-corella","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:24","post_modified_gmt":"2018-12-03 16:18:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dolores-corella\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4534,"post_author":"0","post_date":"2018-12-03 17:18:25","post_date_gmt":"2018-12-03 16:18:25","post_content":"","post_title":"Jordi Salas-Salvad\u00f3","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jordi-salas-salvado","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:25","post_modified_gmt":"2018-12-03 16:18:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jordi-salas-salvado\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4536,"post_author":"0","post_date":"2018-12-03 17:18:26","post_date_gmt":"2018-12-03 16:18:26","post_content":"","post_title":"Emilio Ros","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"emilio-ros","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:26","post_modified_gmt":"2018-12-03 16:18:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/emilio-ros\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18482,"post_author":"0","post_date":"2018-12-03 20:07:33","post_date_gmt":"2018-12-03 19:07:33","post_content":"","post_title":"Rosa Casas","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rosa-casas","to_ping":"","pinged":"","post_modified":"2018-12-03 20:07:33","post_modified_gmt":"2018-12-03 19:07:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rosa-casas\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18483,"post_author":"0","post_date":"2018-12-03 20:07:35","post_date_gmt":"2018-12-03 19:07:35","post_content":"","post_title":"Emilio Sacanella","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"emilio-sacanella","to_ping":"","pinged":"","post_modified":"2018-12-03 20:07:35","post_modified_gmt":"2018-12-03 19:07:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/emilio-sacanella\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18484,"post_author":"0","post_date":"2018-12-03 20:07:37","post_date_gmt":"2018-12-03 19:07:37","post_content":"","post_title":"Mireia Urp\u00ed-Sard\u00e0","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mireia-urpi-sarda","to_ping":"","pinged":"","post_modified":"2018-12-03 20:07:37","post_modified_gmt":"2018-12-03 19:07:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mireia-urpi-sarda\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":13463,"post_author":"0","post_date":"2018-12-03 18:58:30","post_date_gmt":"2018-12-03 17:58:30","post_content":"","post_title":"Olga Castaner","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"olga-castaner","to_ping":"","pinged":"","post_modified":"2018-12-03 18:58:30","post_modified_gmt":"2018-12-03 17:58:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/olga-castaner\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":7295,"post_author":"0","post_date":"2018-12-03 17:47:33","post_date_gmt":"2018-12-03 16:47:33","post_content":"","post_title":"Miguel-\u00c1ngel Mart\u00ednez-Gonz\u00e1lez","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"miguel-angel-martinez-gonzalez-2","to_ping":"","pinged":"","post_modified":"2018-12-03 17:47:33","post_modified_gmt":"2018-12-03 16:47:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/miguel-angel-martinez-gonzalez-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18485,"post_author":"0","post_date":"2018-12-03 20:07:40","post_date_gmt":"2018-12-03 19:07:40","post_content":"","post_title":"Rosa-Mar\u00eda Lamuela-Raventos","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rosa-maria-lamuela-raventos-2","to_ping":"","pinged":"","post_modified":"2018-12-03 20:07:40","post_modified_gmt":"2018-12-03 19:07:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rosa-maria-lamuela-raventos-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1924,"post_author":"0","post_date":"2018-12-03 16:50:41","post_date_gmt":"2018-12-03 15:50:41","post_content":"","post_title":"The Journal of nutrition","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"the-journal-of-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-03 16:50:41","post_modified_gmt":"2018-12-03 15:50:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/the-journal-of-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Long-Term Immunomodulatory Effects of a Mediterranean Diet in Adults at High Risk of Cardiovascular Disease in the PREvenci\u00f3n con DIeta MEDiterr\u00e1nea Randomized Controlled Trial. - Aprifel<\/title>\n<meta name=\"description\" content=\"Long-Term Immunomodulatory Effects of a Mediterranean Diet in Adults at High Risk of Cardiovascular Disease in the PREvenci\u00f3n con DIeta MEDiterr\u00e1nea Randomized Controlled Trial. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" 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