{"id":18331,"date":"2016-10-01T00:00:00","date_gmt":"2018-12-03T19:03:41","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/harnessing-the-power-of-cruciferous-vegetables-developing\/"},"modified":"2018-12-03T20:03:41","modified_gmt":"2018-12-03T19:03:41","slug":"harnessing-the-power-of-cruciferous-vegetables-developing","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/harnessing-the-power-of-cruciferous-vegetables-developing\/","title":{"rendered":"Harnessing the power of cruciferous vegetables: developing a biomarker for Brassica vegetable consumption using urinary 3,3&prime;-diindolylmethane."},"content":{"rendered":"<p style=\"text-align:justify\">Glucobrassicin in Brassica vegetables gives rise to indole-3-carbinol, a compound with potent anti-cancer effects in preclinical models. We previously showed that the urinary metabolite 3,3&#039;-diindolylmethane (DIM) could discriminate between volunteers fed high and low doses of Brassica vegetables. However, the quantitative relationship between glucobrassicin exposure and urinary DIM level is unclear. We conducted a clinical trial to examine the hypotheses that a range of glucobrassicin exposure from Brassica vegetables is reflected in urinary DIM, and that this effect plateaus. Forty-five subjects consumed vegetables, a mixture of Brussels sprouts and\/or cabbage, at 1 of 7 discrete dose levels of glucobrassicin ranging from 25 to 500 &mu;mol, once daily for two consecutive days. All urine was collected for 24 hours after each vegetable-eating session. Urinary DIM was measured using our published liquid chromatography-electrospray ionization-tandem mass spectrometry-selected reaction monitoring (LC\/ESI-MS\/MS-SRM) method. Urinary DIM excretion increased predictably with increasing glucobrassicin dose and plateaued between 200 and 300 &mu;mol of glucobrassicin. The association between glucobrassicin dose and urinary DIM was strong and positive (R(2)=0.68). The majority of DIM was excreted in the first 12 hours after vegetable consumption. We conclude that urinary DIM is a reliable biomarker of glucobrassicin exposure and I3C uptake, and that feeding glucobrassicin beyond 200 &mu;mol did not consistently lead to more urinary DIM, suggesting a plateau in potential chemopreventive benefit.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-18331","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota. Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. fujio002@umn.edu","annee":"2016","mois":"10","numero":"9:10","page":"788-93","auteurs":[{"ID":18321,"post_author":"0","post_date":"2018-12-03 20:03:32","post_date_gmt":"2018-12-03 19:03:32","post_content":"","post_title":"Naomi Fujioka","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"naomi-fujioka","to_ping":"","pinged":"","post_modified":"2018-12-03 20:03:32","post_modified_gmt":"2018-12-03 19:03:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/naomi-fujioka\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18322,"post_author":"0","post_date":"2018-12-03 20:03:33","post_date_gmt":"2018-12-03 19:03:33","post_content":"","post_title":"Benjamin W Ransom","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"benjamin-w-ransom","to_ping":"","pinged":"","post_modified":"2018-12-03 20:03:33","post_modified_gmt":"2018-12-03 19:03:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/benjamin-w-ransom\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18323,"post_author":"0","post_date":"2018-12-03 20:03:34","post_date_gmt":"2018-12-03 19:03:34","post_content":"","post_title":"Steven G Carmella","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"steven-g-carmella","to_ping":"","pinged":"","post_modified":"2018-12-03 20:03:34","post_modified_gmt":"2018-12-03 19:03:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/steven-g-carmella\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18324,"post_author":"0","post_date":"2018-12-03 20:03:35","post_date_gmt":"2018-12-03 19:03:35","post_content":"","post_title":"Pramod Upadhyaya","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pramod-upadhyaya","to_ping":"","pinged":"","post_modified":"2018-12-03 20:03:35","post_modified_gmt":"2018-12-03 19:03:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pramod-upadhyaya\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18325,"post_author":"0","post_date":"2018-12-03 20:03:35","post_date_gmt":"2018-12-03 19:03:35","post_content":"","post_title":"Bruce R Lindgren","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bruce-r-lindgren","to_ping":"","pinged":"","post_modified":"2018-12-03 20:03:35","post_modified_gmt":"2018-12-03 19:03:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/bruce-r-lindgren\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18326,"post_author":"0","post_date":"2018-12-03 20:03:36","post_date_gmt":"2018-12-03 19:03:36","post_content":"","post_title":"Astia Roper-Batker","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"astia-roper-batker","to_ping":"","pinged":"","post_modified":"2018-12-03 20:03:36","post_modified_gmt":"2018-12-03 19:03:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/astia-roper-batker\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18327,"post_author":"0","post_date":"2018-12-03 20:03:37","post_date_gmt":"2018-12-03 19:03:37","post_content":"","post_title":"Dorothy K Hatsukami","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dorothy-k-hatsukami","to_ping":"","pinged":"","post_modified":"2018-12-03 20:03:37","post_modified_gmt":"2018-12-03 19:03:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dorothy-k-hatsukami\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18328,"post_author":"0","post_date":"2018-12-03 20:03:38","post_date_gmt":"2018-12-03 19:03:38","post_content":"","post_title":"Vincent A Fritz","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"vincent-a-fritz","to_ping":"","pinged":"","post_modified":"2018-12-03 20:03:38","post_modified_gmt":"2018-12-03 19:03:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/vincent-a-fritz\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18329,"post_author":"0","post_date":"2018-12-03 20:03:39","post_date_gmt":"2018-12-03 19:03:39","post_content":"","post_title":"Charles Rohwer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"charles-rohwer","to_ping":"","pinged":"","post_modified":"2018-12-03 20:03:39","post_modified_gmt":"2018-12-03 19:03:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/charles-rohwer\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18330,"post_author":"0","post_date":"2018-12-03 20:03:40","post_date_gmt":"2018-12-03 19:03:40","post_content":"","post_title":"Stephen S Hecht","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"stephen-s-hecht","to_ping":"","pinged":"","post_modified":"2018-12-03 20:03:40","post_modified_gmt":"2018-12-03 19:03:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/stephen-s-hecht\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1398,"post_author":"0","post_date":"2018-12-03 15:59:00","post_date_gmt":"2018-12-03 14:59:00","post_content":"","post_title":"Cancer prevention research (Philadelphia, Pa.)","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-prevention-research-philadelphia-pa","to_ping":"","pinged":"","post_modified":"2018-12-03 15:59:00","post_modified_gmt":"2018-12-03 14:59:00","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-prevention-research-philadelphia-pa\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Harnessing the power of cruciferous vegetables: developing a biomarker for Brassica vegetable consumption using urinary 3,3&#039;-diindolylmethane. - Aprifel<\/title>\n<meta name=\"description\" content=\"Harnessing the power of cruciferous vegetables: developing a biomarker for 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