{"id":18037,"date":"2016-08-01T00:00:00","date_gmt":"2018-12-03T18:59:32","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/non-absorbable-apple-procyanidins-prevent-obesity-associated\/"},"modified":"2018-12-03T19:59:32","modified_gmt":"2018-12-03T18:59:32","slug":"non-absorbable-apple-procyanidins-prevent-obesity-associated","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/non-absorbable-apple-procyanidins-prevent-obesity-associated\/","title":{"rendered":"Non-absorbable apple procyanidins prevent obesity associated with gut microbial and metabolomic changes."},"content":{"rendered":"<p style=\"text-align:justify\">Several studies have suggested that flavan-3-ols\/procyanidins are associated with a reduced risk of developing obesity and metabolic syndrome. However, the role of highly polymeric procyanidins (PP), which are major non-absorbable flavonoids, in the biological effects, is not completely understood. Here, we show that 0.5% PP administration for 20 weeks alleviated obesity and regulate expression of genes related to lipid metabolism in C57BL\/6J mice fed a high-fat\/high-sucrose diet. PP-treatment attenuated weight gain and inflammatory effects including lipopolysaccharide and gut permeability. Additionally, metabolic urine profiling using high-performance liquid chromatography-quadrupole time-of-flight\/mass spectrometry demonstrated that PP-treatment decreased the levels of endogenous metabolites associated with insulin resistance. Furthermore, microbial 16S rRNA gene sequencing of the cecum demonstrated that PP administration markedly decreased the Firmicutes\/Bacteroidetes ratio and increased eight times the proportion of Akkermansia. These data suggest that PPs influence the gut microbiota and the intestinal metabolome to produce beneficial effects on metabolic homeostasis.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-18037","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"National Institute of Fruit Tree Science, National Agriculture & Food Research, Tsukuba, Ibaraki, Japan. tshoji@affrc.go.jp","annee":"2016","mois":"8","numero":"6:","page":"31208","auteurs":[{"ID":18031,"post_author":"0","post_date":"2018-12-03 19:59:29","post_date_gmt":"2018-12-03 18:59:29","post_content":"","post_title":"Saeko Masumoto","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"saeko-masumoto","to_ping":"","pinged":"","post_modified":"2018-12-03 19:59:29","post_modified_gmt":"2018-12-03 18:59:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/saeko-masumoto\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18032,"post_author":"0","post_date":"2018-12-03 19:59:29","post_date_gmt":"2018-12-03 18:59:29","post_content":"","post_title":"Akari Terao","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"akari-terao","to_ping":"","pinged":"","post_modified":"2018-12-03 19:59:29","post_modified_gmt":"2018-12-03 18:59:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/akari-terao\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18033,"post_author":"0","post_date":"2018-12-03 19:59:30","post_date_gmt":"2018-12-03 18:59:30","post_content":"","post_title":"Yuji Yamamoto","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yuji-yamamoto","to_ping":"","pinged":"","post_modified":"2018-12-03 19:59:30","post_modified_gmt":"2018-12-03 18:59:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/yuji-yamamoto\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18034,"post_author":"0","post_date":"2018-12-03 19:59:30","post_date_gmt":"2018-12-03 18:59:30","post_content":"","post_title":"Takao Mukai","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"takao-mukai","to_ping":"","pinged":"","post_modified":"2018-12-03 19:59:30","post_modified_gmt":"2018-12-03 18:59:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/takao-mukai\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18035,"post_author":"0","post_date":"2018-12-03 19:59:31","post_date_gmt":"2018-12-03 18:59:31","post_content":"","post_title":"Tomisato Miura","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"tomisato-miura","to_ping":"","pinged":"","post_modified":"2018-12-03 19:59:31","post_modified_gmt":"2018-12-03 18:59:31","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/tomisato-miura\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18036,"post_author":"0","post_date":"2018-12-03 19:59:32","post_date_gmt":"2018-12-03 18:59:32","post_content":"","post_title":"Toshihiko Shoji","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"toshihiko-shoji","to_ping":"","pinged":"","post_modified":"2018-12-03 19:59:32","post_modified_gmt":"2018-12-03 18:59:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/toshihiko-shoji\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":5093,"post_author":"0","post_date":"2018-12-03 17:24:11","post_date_gmt":"2018-12-03 16:24:11","post_content":"","post_title":"Scientific reports","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"scientific-reports","to_ping":"","pinged":"","post_modified":"2018-12-03 17:24:11","post_modified_gmt":"2018-12-03 16:24:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/scientific-reports\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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