{"id":17811,"date":"2016-09-01T00:00:00","date_gmt":"2018-12-03T18:56:47","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/comparing-metabolite-profiles-of-habitual-diet-in-serum-and\/"},"modified":"2018-12-03T19:56:47","modified_gmt":"2018-12-03T18:56:47","slug":"comparing-metabolite-profiles-of-habitual-diet-in-serum-and","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/comparing-metabolite-profiles-of-habitual-diet-in-serum-and\/","title":{"rendered":"Comparing metabolite profiles of habitual diet in serum and urine."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>BACKGROUND<\/strong><br \/>\nDiet plays an important role in chronic disease etiology, but some diet-disease associations remain inconclusive because of methodologic limitations in dietary assessment. Metabolomics is a novel method for identifying objective dietary biomarkers, although it is unclear what dietary information is captured from metabolites found in serum compared with urine.<\/p>\n<p style=\"text-align:justify\"><strong>OBJECTIVE<\/strong><br \/>\nWe compared metabolite profiles of habitual diet measured from serum with those measured from urine.<\/p>\n<p style=\"text-align:justify\"><strong>DESIGN<\/strong><br \/>\nWe first estimated correlations between consumption of 56 foods, beverages, and supplements assessed by a food-frequency questionnaire, with 676 serum and 848 urine metabolites identified by untargeted liquid chromatography mass spectrometry, ultra-high performance liquid chromatography tandem mass spectrometry, and gas chromatography mass spectrometry in a colon adenoma case-control study (n = 125 cases and 128 controls) while adjusting for age, sex, smoking, fasting, case-control status, body mass index, physical activity, education, and caloric intake. We controlled for multiple comparisons with the use of a false discovery rate of &lt;0.1. Next, we created serum and urine multiple-metabolite models to predict food intake with the use of 10-fold crossvalidation least absolute shrinkage and selection operator regression for 80% of the data; predicted values were created in the remaining 20%. Finally, we compared predicted values with estimates obtained from self-reported intake for metabolites measured in serum and urine.<\/p>\n<p style=\"text-align:justify\"><strong>RESULTS<\/strong><br \/>\nWe identified metabolites associated with 46 of 56 dietary items; 417 urine and 105 serum metabolites were correlated with &ge;1 food, beverage, or supplement. More metabolites in urine (n = 154) than in serum (n = 39) were associated uniquely with one food. We found previously unreported metabolite associations with leafy green vegetables, sugar-sweetened beverages, citrus, added sugar, red meat, shellfish, desserts, and wine. Prediction of dietary intake from multiple-metabolite profiles was similar between biofluids.<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSIONS<\/strong><br \/>\nCandidate metabolite biomarkers of habitual diet are identifiable in both serum and urine. Urine samples offer a valid alternative or complement to serum for metabolite biomarkers of diet in large-scale clinical or epidemiologic studies.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-17811","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Yale School of Public Health, Yale University, New Haven, CT; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD; mary.playdon@nih.gov","annee":"2016","mois":"9","numero":"104:3","page":"776-89","auteurs":[{"ID":9053,"post_author":"0","post_date":"2018-12-03 18:06:51","post_date_gmt":"2018-12-03 17:06:51","post_content":"","post_title":"Susan T Mayne","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"susan-t-mayne","to_ping":"","pinged":"","post_modified":"2018-12-03 18:06:51","post_modified_gmt":"2018-12-03 17:06:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/susan-t-mayne\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17803,"post_author":"0","post_date":"2018-12-03 19:56:43","post_date_gmt":"2018-12-03 18:56:43","post_content":"","post_title":"Melinda L Irwin","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"melinda-l-irwin","to_ping":"","pinged":"","post_modified":"2018-12-03 19:56:43","post_modified_gmt":"2018-12-03 18:56:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/melinda-l-irwin\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17804,"post_author":"0","post_date":"2018-12-03 19:56:43","post_date_gmt":"2018-12-03 18:56:43","post_content":"","post_title":"Rashmi Sinha","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rashmi-sinha","to_ping":"","pinged":"","post_modified":"2018-12-03 19:56:43","post_modified_gmt":"2018-12-03 18:56:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rashmi-sinha\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":14000,"post_author":"0","post_date":"2018-12-03 19:04:41","post_date_gmt":"2018-12-03 18:04:41","post_content":"","post_title":"Amanda J Cross","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"amanda-j-cross","to_ping":"","pinged":"","post_modified":"2018-12-03 19:04:41","post_modified_gmt":"2018-12-03 18:04:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/amanda-j-cross\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9055,"post_author":"0","post_date":"2018-12-03 18:06:52","post_date_gmt":"2018-12-03 17:06:52","post_content":"","post_title":"Mary C Playdon","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mary-c-playdon","to_ping":"","pinged":"","post_modified":"2018-12-03 18:06:52","post_modified_gmt":"2018-12-03 17:06:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mary-c-playdon\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17805,"post_author":"0","post_date":"2018-12-03 19:56:44","post_date_gmt":"2018-12-03 18:56:44","post_content":"","post_title":"Joshua N Sampson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"joshua-n-sampson","to_ping":"","pinged":"","post_modified":"2018-12-03 19:56:44","post_modified_gmt":"2018-12-03 18:56:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/joshua-n-sampson\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17806,"post_author":"0","post_date":"2018-12-03 19:56:44","post_date_gmt":"2018-12-03 18:56:44","post_content":"","post_title":"Kristin A Guertin","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kristin-a-guertin","to_ping":"","pinged":"","post_modified":"2018-12-03 19:56:44","post_modified_gmt":"2018-12-03 18:56:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/kristin-a-guertin\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17807,"post_author":"0","post_date":"2018-12-03 19:56:45","post_date_gmt":"2018-12-03 18:56:45","post_content":"","post_title":"Kristin A Moy","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kristin-a-moy","to_ping":"","pinged":"","post_modified":"2018-12-03 19:56:45","post_modified_gmt":"2018-12-03 18:56:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/kristin-a-moy\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17808,"post_author":"0","post_date":"2018-12-03 19:56:45","post_date_gmt":"2018-12-03 18:56:45","post_content":"","post_title":"Nathaniel Rothman","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nathaniel-rothman","to_ping":"","pinged":"","post_modified":"2018-12-03 19:56:45","post_modified_gmt":"2018-12-03 18:56:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/nathaniel-rothman\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17809,"post_author":"0","post_date":"2018-12-03 19:56:46","post_date_gmt":"2018-12-03 18:56:46","post_content":"","post_title":"Rachael Stolzenberg-Solomon","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rachael-stolzenberg-solomon","to_ping":"","pinged":"","post_modified":"2018-12-03 19:56:46","post_modified_gmt":"2018-12-03 18:56:46","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rachael-stolzenberg-solomon\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17810,"post_author":"0","post_date":"2018-12-03 19:56:47","post_date_gmt":"2018-12-03 18:56:47","post_content":"","post_title":"Steven C Moore","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"steven-c-moore","to_ping":"","pinged":"","post_modified":"2018-12-03 19:56:47","post_modified_gmt":"2018-12-03 18:56:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/steven-c-moore\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1719,"post_author":"0","post_date":"2018-12-03 16:01:56","post_date_gmt":"2018-12-03 15:01:56","post_content":"","post_title":"The American journal of clinical nutrition","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"the-american-journal-of-clinical-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:56","post_modified_gmt":"2018-12-03 15:01:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/the-american-journal-of-clinical-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Comparing metabolite profiles of habitual diet in serum and urine. - Aprifel<\/title>\n<meta name=\"description\" content=\"Comparing metabolite profiles of habitual diet in serum and urine. - Aprifel\" \/>\n<meta name=\"robots\" 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