{"id":17677,"date":"2016-11-01T00:00:00","date_gmt":"2018-12-03T18:55:12","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/is-there-an-interplay-between-adherence-to-mediterranean-diet\/"},"modified":"2018-12-03T19:55:12","modified_gmt":"2018-12-03T18:55:12","slug":"is-there-an-interplay-between-adherence-to-mediterranean-diet","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/is-there-an-interplay-between-adherence-to-mediterranean-diet\/","title":{"rendered":"Is there an interplay between adherence to Mediterranean diet, antioxidant status and vascular disease in atrial fibrillation patients?"},"content":{"rendered":"<p style=\"text-align:justify\">Mediterranean Diet (Med-Diet) is associated with reduced incidence of vascular events (VEs) in atrial fibrillation (AF), but the mechanism accounting for its beneficial effect is only partially known. We hypothesized that Med-Diet may reduce VEs by improving antioxidant status, as assessed by glutathione peroxidase 3 (GPx3) and superoxide dismutase (SOD). We performed a prospective cohort study investigating the relationship between adherence to Med-Diet, serum baseline GPx3 and SOD activities, and the occurrence of vascular events (VEs) in 690 AF patients. GPx3 activity was directly associated with Med-Diet score (B=0.192, p&lt;0.001) and inversely with age (B=-0.124, p=0.001), after adjustment for potential confounders; Med-Diet weakly affected SOD levels. During a mean follow-up of 46.1&plusmn;28.2 months, 89 VEs were recorded; patients with VEs had lower GPx3 levels compared to those without (p=0.002); no differences regarding SOD activity were found. Multivariable Cox regression analysis showed that age (Hazard ratio [HR]:1.065, p&lt;0.001), logGPx3 (above median, HR:0.629, p&lt;0.05) and Med-Diet score (HR:0.547, p&lt;0.05) predicted VEs. Med-Diet favourably modulates antioxidant activity of GPx3 in AF resulting in reduced VEs rate. We hypothesize that modulating GPx3 levels by Med-Diet could represent an additional nutritional strategy to prevent VEs in AF patients.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-17677","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Sapienza University of Rome, Internal Medicine and Medical Specialties , Viale del Policlinico 155 , Rome, Italy.\r\ndaniele.pastori@uniroma1.it","annee":"2016","mois":"11","numero":"25:14","page":"751-55","auteurs":[{"ID":9647,"post_author":"0","post_date":"2018-12-03 18:13:32","post_date_gmt":"2018-12-03 17:13:32","post_content":"","post_title":"Daniele Pastori","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"daniele-pastori","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:32","post_modified_gmt":"2018-12-03 17:13:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/daniele-pastori\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9648,"post_author":"0","post_date":"2018-12-03 18:13:33","post_date_gmt":"2018-12-03 17:13:33","post_content":"","post_title":"Roberto Carnevale","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"roberto-carnevale","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:33","post_modified_gmt":"2018-12-03 17:13:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/roberto-carnevale\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17674,"post_author":"0","post_date":"2018-12-03 19:55:10","post_date_gmt":"2018-12-03 18:55:10","post_content":"","post_title":"Simona Bartimoccia","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"simona-bartimoccia","to_ping":"","pinged":"","post_modified":"2018-12-03 19:55:10","post_modified_gmt":"2018-12-03 18:55:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/simona-bartimoccia\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9649,"post_author":"0","post_date":"2018-12-03 18:13:33","post_date_gmt":"2018-12-03 17:13:33","post_content":"","post_title":"Cristina Nocella","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cristina-nocella","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:33","post_modified_gmt":"2018-12-03 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Pignatelli","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pasquale-pignatelli","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:34","post_modified_gmt":"2018-12-03 17:13:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pasquale-pignatelli\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9652,"post_author":"0","post_date":"2018-12-03 18:13:35","post_date_gmt":"2018-12-03 17:13:35","post_content":"","post_title":"Danilo Menichelli","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"danilo-menichelli","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:35","post_modified_gmt":"2018-12-03 17:13:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/danilo-menichelli\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":17675,"post_author":"0","post_date":"2018-12-03 19:55:11","post_date_gmt":"2018-12-03 18:55:11","post_content":"","post_title":"Isabella Leo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"isabella-leo","to_ping":"","pinged":"","post_modified":"2018-12-03 19:55:11","post_modified_gmt":"2018-12-03 18:55:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/isabella-leo\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9653,"post_author":"0","post_date":"2018-12-03 18:13:35","post_date_gmt":"2018-12-03 17:13:35","post_content":"","post_title":"Marta Novo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"marta-novo","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:35","post_modified_gmt":"2018-12-03 17:13:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/marta-novo\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":17676,"post_author":"0","post_date":"2018-12-03 19:55:12","post_date_gmt":"2018-12-03 18:55:12","post_content":"","post_title":"Antioxidants &amp; redox signaling","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"antioxidants-redox-signaling","to_ping":"","pinged":"","post_modified":"2018-12-03 19:55:12","post_modified_gmt":"2018-12-03 18:55:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/antioxidants-redox-signaling\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Is there an interplay between adherence to Mediterranean diet, antioxidant status and vascular disease in atrial fibrillation patients? - Aprifel<\/title>\n<meta name=\"description\" content=\"Is there an interplay between adherence to Mediterranean diet, antioxidant status and vascular disease in atrial fibrillation patients? - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Is there an interplay between adherence to Mediterranean 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