{"id":16723,"date":"2016-11-01T00:00:00","date_gmt":"2018-12-03T18:42:31","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/agricultural-exposure-and-risk-of-bladder-cancer-in-the-agriculture\/"},"modified":"2018-12-03T19:42:31","modified_gmt":"2018-12-03T18:42:31","slug":"agricultural-exposure-and-risk-of-bladder-cancer-in-the-agriculture","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/agricultural-exposure-and-risk-of-bladder-cancer-in-the-agriculture\/","title":{"rendered":"Agricultural exposure and risk of bladder cancer in the AGRIculture and CANcer cohort."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>PURPOSE<\/strong><br \/>\nLiterature on agricultural activities and bladder cancer risk is scarce. However, farmers can be subjected to carcinogenic exposure (e.g. arsenic, previously used as a pesticide in France). This study aimed at assessing the role of a large range of agricultural activities and tasks on bladder cancer risk.<\/p>\n<p style=\"text-align:justify\"><strong>METHODS<\/strong><br \/>\nThe study population was the AGRIculture and CANcer cohort, a large prospective cohort of individuals affiliated to the agricultural health insurance scheme (MSA) in France. Incident bladder cancers were identified by cancer registries from enrolment (2005-2007) to 2009. Data on agricultural exposure during professional lifetime (5 animals, 13 crops, specific tasks) were obtained from the enrolment questionnaire. Associations between bladder cancer and agricultural exposure were analysed using a Cox model, adjusted for gender and smoking history.<\/p>\n<p style=\"text-align:justify\"><strong>RESULTS<\/strong><br \/>\nAmong the 148,051 farm owners and workers included in this analysis, 179 incident bladder cancers were identified. We observed an elevated risk among field-grown vegetable workers [HR 1.89, 95% CI (1.20-2.99)], with an exposure-response relationship with duration of work [&ge;30&nbsp;years: HR 2.54, 95% CI (1.11-5.83), p-trend&nbsp;=&nbsp;0.02], and higher risk among women [HR 3.82, 95% CI (1.58-9.25), p-interaction&nbsp;=&nbsp;0.05]. Non-significantly increased risks were also observed in greenhouse farmers (HR&nbsp;=&nbsp;1.95), pea sowing (HR&nbsp;=&nbsp;1.84), rape sowing (HR&nbsp;=&nbsp;1.64); several tasks involving pesticide use, especially seed treatment (HR&nbsp;=&nbsp;1.24); and in activities and tasks potentially exposing to arsenic compounds via pesticide use (HR&nbsp;=&nbsp;1.49) or re-entry tasks (HR&nbsp;=&nbsp;1.63).<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSIONS<\/strong><br \/>\nOur analyses raise the question of a possible link between agricultural activity, especially field-grown vegetables, and greenhouse cultivation and bladder cancer.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-16723","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"UMR 1086 Cancers et Pr\u00e9ventions, INSERM, Caen, France. mathilde.boulanger@unicaen.fr","annee":"2016","mois":"11","numero":":","page":"","auteurs":[{"ID":3315,"post_author":"0","post_date":"2018-12-03 17:04:22","post_date_gmt":"2018-12-03 16:04:22","post_content":"","post_title":"Mathilde Boulanger","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mathilde-boulanger","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:22","post_modified_gmt":"2018-12-03 16:04:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mathilde-boulanger\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3316,"post_author":"0","post_date":"2018-12-03 17:04:23","post_date_gmt":"2018-12-03 16:04:23","post_content":"","post_title":"S\u00e9verine Tual","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"severine-tual","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:23","post_modified_gmt":"2018-12-03 16:04:23","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/severine-tual\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3317,"post_author":"0","post_date":"2018-12-03 17:04:23","post_date_gmt":"2018-12-03 16:04:23","post_content":"","post_title":"Cl\u00e9mentine Lemarchand","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"clementine-lemarchand","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:23","post_modified_gmt":"2018-12-03 16:04:23","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/clementine-lemarchand\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3318,"post_author":"0","post_date":"2018-12-03 17:04:24","post_date_gmt":"2018-12-03 16:04:24","post_content":"","post_title":"Anne-Val\u00e9rie Guizard","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"anne-valerie-guizard","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:24","post_modified_gmt":"2018-12-03 16:04:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/anne-valerie-guizard\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":16721,"post_author":"0","post_date":"2018-12-03 19:42:30","post_date_gmt":"2018-12-03 18:42:30","post_content":"","post_title":"Michel Velten","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"michel-velten","to_ping":"","pinged":"","post_modified":"2018-12-03 19:42:30","post_modified_gmt":"2018-12-03 18:42:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/michel-velten\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3319,"post_author":"0","post_date":"2018-12-03 17:04:24","post_date_gmt":"2018-12-03 16:04:24","post_content":"","post_title":"Elisabeth Marcotullio","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"elisabeth-marcotullio","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:24","post_modified_gmt":"2018-12-03 16:04:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/elisabeth-marcotullio\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3320,"post_author":"0","post_date":"2018-12-03 17:04:25","post_date_gmt":"2018-12-03 16:04:25","post_content":"","post_title":"Isabelle Baldi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"isabelle-baldi","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:25","post_modified_gmt":"2018-12-03 16:04:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/isabelle-baldi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3321,"post_author":"0","post_date":"2018-12-03 17:04:25","post_date_gmt":"2018-12-03 16:04:25","post_content":"","post_title":"B\u00e9n\u00e9dicte Clin","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"benedicte-clin","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:25","post_modified_gmt":"2018-12-03 16:04:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/benedicte-clin\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3322,"post_author":"0","post_date":"2018-12-03 17:04:26","post_date_gmt":"2018-12-03 16:04:26","post_content":"","post_title":"Pierre Lebailly","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pierre-lebailly","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:26","post_modified_gmt":"2018-12-03 16:04:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pierre-lebailly\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":16722,"post_author":"0","post_date":"2018-12-03 19:42:31","post_date_gmt":"2018-12-03 18:42:31","post_content":"","post_title":"INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"international-archives-of-occupational-and-environmental-health","to_ping":"","pinged":"","post_modified":"2018-12-03 19:42:31","post_modified_gmt":"2018-12-03 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