{"id":14430,"date":"2017-04-01T00:00:00","date_gmt":"2018-12-03T18:09:35","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/a-pooled-analysis-of-15-prospective-cohort-studies-on-the-association\/"},"modified":"2018-12-03T19:09:35","modified_gmt":"2018-12-03T18:09:35","slug":"a-pooled-analysis-of-15-prospective-cohort-studies-on-the-association","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/a-pooled-analysis-of-15-prospective-cohort-studies-on-the-association\/","title":{"rendered":"A Pooled Analysis of 15 Prospective Cohort Studies on the Association Between Fruit, Vegetable, and Mature Bean Consumption and Risk of Prostate Cancer."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>BACKGROUND<\/strong><br \/>\nRelationships between fruit, vegetable, and mature bean consumption and prostate cancer risk are unclear.<\/p>\n<p style=\"text-align:justify\"><strong>METHODS<\/strong><br \/>\nWe examined associations between fruit and vegetable groups, specific fruits and vegetables, and mature bean consumption and prostate cancer risk overall, by stage and grade, and for prostate cancer mortality in a pooled analysis of 15 prospective cohorts, including 52,680 total cases and 3,205 prostate cancer deaths among 842,149 men. Diet was measured by a food frequency questionnaire or similar instrument at baseline. We calculated study-specific relative risks using Cox proportional hazards regression, and then pooled these estimates using a random effects model.<\/p>\n<p style=\"text-align:justify\"><strong>RESULTS<\/strong><br \/>\nWe did not observe any statistically significant associations for advanced prostate cancer or prostate cancer mortality with any food group (including total fruits and vegetables, total fruits, total vegetables, fruit and vegetable juice, cruciferous vegetables, and tomato products), nor specific fruit and vegetables. Additionally, we observed few statistically significant results for other prostate cancer outcomes. Pooled multivariable relative risks comparing the highest versus lowest quantiles across all fruit and vegetable exposures and prostate cancer outcomes ranged from 0.89 to 1.09. There was no evidence of effect modification for any association by age or body mass index.<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSIONS AND IMPACT<\/strong><br \/>\nResults from this large, international, pooled analysis do not support a strong role of fruits, vegetables (including cruciferous vegetables and tomato products, although few studies assessed tomato sources of more bioavailable lycopene, the potential cancer preventive agent in tomatoes), or mature beans in prostate cancer.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-14430","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Nutrition, Harvard T.H. 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