{"id":14312,"date":"2017-04-01T00:00:00","date_gmt":"2018-12-03T18:08:13","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-men-s-eating-and-living-meal-study-calgb-70807-alliance\/"},"modified":"2018-12-03T19:08:13","modified_gmt":"2018-12-03T18:08:13","slug":"the-men-s-eating-and-living-meal-study-calgb-70807-alliance","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-men-s-eating-and-living-meal-study-calgb-70807-alliance\/","title":{"rendered":"The Men’s Eating and Living (MEAL) Study (CALGB 70807 [Alliance]): Recruitment Feasibility and Baseline Demographics of a Randomized Trial of Diet in Men on Active Surveillance for Prostate Cancer."},"content":{"rendered":"

OBJECTIVE<\/strong>
\nTo assess the feasibility of performing national, randomized trials of dietary interventions for localized prostate cancer.<\/p>\n

METHODS<\/strong>
\nThe Men's Eating and Living (MEAL) Study (CALGB 70807 [Alliance]) is a phase 3 clinical trial testing the efficacy of a high-vegetable diet to prevent progression in prostate cancer patients on active surveillance. Participants were randomized to a validated diet counseling intervention or a control condition. Chi-Square and Kruskal Wallis analyses were used to assess between-group differences at baseline.<\/p>\n

RESULTS<\/strong>
\nFrom 2011 to 2015, 478 (103%) of a targeted 464 patients were randomized at 91 study sites. At baseline, mean (SD) age was 64 (6) years and PSA 4.9 (2.1) ng\/mL. Fifty-six (12%) participants were African-American, 17 (4%) Hispanic\/Latino, and 16 (3%) Asian-American. There were no significant between-group differences for age (p-value = 0.98), race\/ethnicity (p-value = 0.52), geographic region (p-value = 0.60), time since prostate cancer diagnosis (p-value = 0.85), PSA (p-value = 0.96), clinical stage (T1c or T2a, p-value = 0.27), or Gleason sum (Gleason 6 or 3+4 = 7, p-value = 0.76). In a pre-planned analysis, the baseline prostate biopsy samples of the first 50 patients underwent central pathology review to confirm eligibility, with an expectation that <10% would become ineligible. One (2%) of 50 patients became ineligible.<\/p>\n

CONCLUSION<\/strong>
\nThe MEAL Study demonstrates the feasibility of implementing national, multi-institutional phase 3 clinical trials of diet for prostate cancer and of testing interventions to prevent disease progression in active surveillance. This article is protected by copyright. All rights reserved.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-14312","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Division of Urologic Oncology, UC San Diego Moores Comprehensive Cancer Center; Department of Urology, UC San Diego Health System; and VA San Diego Healthcare System, La Jolla, CA.","annee":"2017","mois":"4","numero":"","page":"","auteurs":[{"ID":1131,"post_author":"0","post_date":"2018-12-03 15:56:37","post_date_gmt":"2018-12-03 14:56:37","post_content":"","post_title":"J Kellogg Parsons","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"j-kellogg-parsons","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:37","post_modified_gmt":"2018-12-03 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