{"id":13590,"date":"2017-06-01T00:00:00","date_gmt":"2018-12-03T17:59:54","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-baseline-nutritional-status-on-long-term-multivitamin\/"},"modified":"2018-12-03T18:59:54","modified_gmt":"2018-12-03T17:59:54","slug":"effect-of-baseline-nutritional-status-on-long-term-multivitamin","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-baseline-nutritional-status-on-long-term-multivitamin\/","title":{"rendered":"Effect of Baseline Nutritional Status on Long-term Multivitamin Use and Cardiovascular Disease Risk: A Secondary Analysis of the Physicians&rsquo; Health Study II Randomized Clinical Trial."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>Importance<\/strong><br \/>\nLong-term multivitamin use had no effect on risk of cardiovascular disease (CVD) in the Physicians&#039; Health Study II. Baseline nutritional status may have modified the lack of effect.<\/p>\n<p style=\"text-align:justify\"><strong>Objective<\/strong><br \/>\nTo investigate effect modification by various baseline dietary factors on CVD risk in the Physicians&#039; Health Study II.<\/p>\n<p style=\"text-align:justify\"><strong>Design, Setting, and Participants<\/strong><br \/>\nThe Physicians&#039; Health Study II was a randomized, double-blind, placebo-controlled trial testing multivitamin use (multivitamin [Centrum Silver] or placebo daily) among US male physicians. The Physicians&#039; Health Study II included 14\u202f641 male physicians 50 years or older, 13\u202f316 of whom (91.0%) completed a baseline 116-item semiquantitative food frequency questionnaire and were included in the analyses. This study examined effect modification by baseline intake of key foods, individual nutrients, dietary patterns (Alternate Healthy Eating Index and Alternate Mediterranean Diet Score), and dietary supplement use. The study began in 1997, with continued treatment and follow-up through June 1, 2011.<\/p>\n<p style=\"text-align:justify\"><strong>Interventions<\/strong><br \/>\nMultivitamin or placebo daily.<\/p>\n<p style=\"text-align:justify\"><strong>Main Outcomes and Measures<\/strong><br \/>\nMajor cardiovascular events, including nonfatal myocardial infarction, nonfatal stroke, and CVD mortality. Secondary outcomes included myocardial infarction, total stroke, CVD mortality, and total mortality individually.<\/p>\n<p style=\"text-align:justify\"><strong>Results<\/strong><br \/>\nIn total, 13\u202f316 male physicians (mean [SD] age at randomization, 64.0 [9.0] years in those receiving the active multivitamin and 64.0 [9.1] years in those receiving the placebo) were observed for a mean (SD) follow-up of 11.4 (2.3) years. There was no consistent evidence of effect modification by various foods, nutrients, dietary patterns, or baseline supplement use on the effect of multivitamin use on CVD end points. Statistically significant interaction effects were observed between multivitamin use and vitamin B6 intake on myocardial infarction, between multivitamin use and vitamin D intake on CVD mortality, and between multivitamin use and vitamin B12 intake on CVD mortality and total mortality. However, there were inconsistent patterns in hazard ratios across tertiles of each dietary factor that are likely explained by multiple testing.<\/p>\n<p style=\"text-align:justify\"><strong>Conclusions and Relevance<\/strong><br \/>\nThe results suggest that baseline nutritional status does not influence the effect of randomized long-term multivitamin use on major CVD events. Future studies are needed to investigate the role of baseline nutritional biomarkers on the effect of multivitamin use on CVD and other outcomes.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-13590","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts2Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.","annee":"2017","mois":"6","numero":"2:6","page":"617-25","auteurs":[{"ID":13581,"post_author":"0","post_date":"2018-12-03 18:59:49","post_date_gmt":"2018-12-03 17:59:49","post_content":"","post_title":"Susanne Rautiainen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"susanne-rautiainen","to_ping":"","pinged":"","post_modified":"2018-12-03 18:59:49","post_modified_gmt":"2018-12-03 17:59:49","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/susanne-rautiainen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":13582,"post_author":"0","post_date":"2018-12-03 18:59:50","post_date_gmt":"2018-12-03 17:59:50","post_content":"","post_title":"J Michael Gaziano","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"j-michael-gaziano","to_ping":"","pinged":"","post_modified":"2018-12-03 18:59:50","post_modified_gmt":"2018-12-03 17:59:50","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/j-michael-gaziano\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":13583,"post_author":"0","post_date":"2018-12-03 18:59:51","post_date_gmt":"2018-12-03 17:59:51","post_content":"","post_title":"Howard D Sesso","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"howard-d-sesso","to_ping":"","pinged":"","post_modified":"2018-12-03 18:59:51","post_modified_gmt":"2018-12-03 17:59:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/howard-d-sesso\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4220,"post_author":"0","post_date":"2018-12-03 17:13:34","post_date_gmt":"2018-12-03 16:13:34","post_content":"","post_title":"Joann E Manson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"joann-e-manson","to_ping":"","pinged":"","post_modified":"2018-12-03 17:13:34","post_modified_gmt":"2018-12-03 16:13:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/joann-e-manson\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":13584,"post_author":"0","post_date":"2018-12-03 18:59:51","post_date_gmt":"2018-12-03 17:59:51","post_content":"","post_title":"William G Christen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"william-g-christen","to_ping":"","pinged":"","post_modified":"2018-12-03 18:59:51","post_modified_gmt":"2018-12-03 17:59:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/william-g-christen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":13585,"post_author":"0","post_date":"2018-12-03 18:59:52","post_date_gmt":"2018-12-03 17:59:52","post_content":"","post_title":"Vadim Bubes","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"vadim-bubes","to_ping":"","pinged":"","post_modified":"2018-12-03 18:59:52","post_modified_gmt":"2018-12-03 17:59:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/vadim-bubes\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":13586,"post_author":"0","post_date":"2018-12-03 18:59:52","post_date_gmt":"2018-12-03 17:59:52","post_content":"","post_title":"Gregory Kotler","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gregory-kotler","to_ping":"","pinged":"","post_modified":"2018-12-03 18:59:52","post_modified_gmt":"2018-12-03 17:59:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/gregory-kotler\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":13587,"post_author":"0","post_date":"2018-12-03 18:59:53","post_date_gmt":"2018-12-03 17:59:53","post_content":"","post_title":"Robert J Glynn","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"robert-j-glynn","to_ping":"","pinged":"","post_modified":"2018-12-03 18:59:53","post_modified_gmt":"2018-12-03 17:59:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/robert-j-glynn\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":13588,"post_author":"0","post_date":"2018-12-03 18:59:53","post_date_gmt":"2018-12-03 17:59:53","post_content":"","post_title":"Julie E Buring","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"julie-e-buring","to_ping":"","pinged":"","post_modified":"2018-12-03 18:59:53","post_modified_gmt":"2018-12-03 17:59:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/julie-e-buring\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":13589,"post_author":"0","post_date":"2018-12-03 18:59:54","post_date_gmt":"2018-12-03 17:59:54","post_content":"","post_title":"JAMA cardiology","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jama-cardiology","to_ping":"","pinged":"","post_modified":"2018-12-03 18:59:54","post_modified_gmt":"2018-12-03 17:59:54","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/jama-cardiology\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Effect of Baseline Nutritional Status on Long-term Multivitamin Use and Cardiovascular Disease Risk: A Secondary Analysis of the Physicians&#039; Health Study II Randomized Clinical Trial. - Aprifel<\/title>\n<meta name=\"description\" content=\"Effect of Baseline Nutritional Status on Long-term Multivitamin Use and Cardiovascular Disease Risk: A Secondary Analysis of the Physicians&#039; Health Study II Randomized Clinical Trial. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" 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