{"id":12259,"date":"2017-09-01T00:00:00","date_gmt":"2018-12-03T17:44:32","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/brassica-derived-plant-bioactives-as-modulators-of-chemopreventive\/"},"modified":"2018-12-03T18:44:32","modified_gmt":"2018-12-03T17:44:32","slug":"brassica-derived-plant-bioactives-as-modulators-of-chemopreventive","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/brassica-derived-plant-bioactives-as-modulators-of-chemopreventive\/","title":{"rendered":"Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways."},"content":{"rendered":"<p style=\"text-align:justify\">A high consumption of vegetables belonging to the Brassicaceae family has been related to a lower incidence of chronic diseases including different kinds of cancer. These beneficial effects of, e.g., broccoli, cabbage or rocket (arugula) intake have been mainly dedicated to the sulfur-containing glucosinolates (GLSs)-secondary plant compounds nearly exclusively present in Brassicaceae-and in particular to their bioactive breakdown products including isothiocyanates (ITCs). Overall, the current literature indicate that selected Brassica-derived ITCs exhibit health-promoting effects in vitro, as well as in laboratory mice in vivo. Some studies suggest anti-carcinogenic and anti-inflammatory properties for ITCs which may be communicated through an activation of the redox-sensitive transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) that controls the expression of antioxidant and phase II enzymes. Furthermore, it has been shown that ITCs are able to significantly ameliorate a severe inflammatory phenotype in colitic mice in vivo. As there are studies available suggesting an epigenetic mode of action for Brassica-derived phytochemicals, the conduction of further studies would be recommendable to investigate if the beneficial effects of these compounds also persist during an irregular consumption pattern.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-12259","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Institute of Nutritional Medicine, University of L\u00fcbeck, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany. christine.schuemann@gmail.com.","annee":"2017","mois":"9","numero":"18:9","page":"","auteurs":[{"ID":12257,"post_author":"0","post_date":"2018-12-03 18:44:31","post_date_gmt":"2018-12-03 17:44:31","post_content":"","post_title":"Christine Sturm","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"christine-sturm","to_ping":"","pinged":"","post_modified":"2018-12-03 18:44:31","post_modified_gmt":"2018-12-03 17:44:31","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/christine-sturm\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12258,"post_author":"0","post_date":"2018-12-03 18:44:32","post_date_gmt":"2018-12-03 17:44:32","post_content":"","post_title":"Anika E Wagner","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"anika-e-wagner","to_ping":"","pinged":"","post_modified":"2018-12-03 18:44:32","post_modified_gmt":"2018-12-03 17:44:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/anika-e-wagner\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":6547,"post_author":"0","post_date":"2018-12-03 17:39:22","post_date_gmt":"2018-12-03 16:39:22","post_content":"","post_title":"International journal of molecular sciences","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"international-journal-of-molecular-sciences","to_ping":"","pinged":"","post_modified":"2018-12-03 17:39:22","post_modified_gmt":"2018-12-03 16:39:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/international-journal-of-molecular-sciences\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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