{"id":12184,"date":"2017-07-01T00:00:00","date_gmt":"2018-12-03T17:43:41","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-role-of-sulforaphane-in-cancer-chemoprevention-and-health\/"},"modified":"2018-12-03T18:43:41","modified_gmt":"2018-12-03T17:43:41","slug":"the-role-of-sulforaphane-in-cancer-chemoprevention-and-health","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-role-of-sulforaphane-in-cancer-chemoprevention-and-health\/","title":{"rendered":"The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review."},"content":{"rendered":"<p style=\"text-align:justify\">Cancer is a multi-stage process resulting from aberrant signaling pathways driving uncontrolled proliferation of transformed cells. The development and progression of cancer from a premalignant lesion towards a metastatic tumor requires accumulation of mutations in many regulatory genes of the cell. Different chemopreventative approaches have been sought to interfere with initiation and control malignant progression. Here we present research on dietary compounds with evidence of cancer prevention activity that highlights the potential beneficial effect of a diet rich in cruciferous vegetables. The Brassica family of cruciferous vegetables such as broccoli is a rich source of glucosinolates, which are metabolized to isothiocyanate compounds. Amongst a number of related variants of isothiocyanates, sulforaphane (SFN) has surfaced as a particularly potent chemopreventive agent based on its ability to target multiple mechanisms within the cell to control carcinogenesis. Anti-inflammatory, pro-apoptotic and modulation of histones are some of the more important and known mechanisms by which SFN exerts chemoprevention. The effect of SFN on cancer stem cells is another area of interest that has been explored in recent years and may contribute to its chemopreventive properties. In this paper, we briefly review structure, pharmacology and preclinical studies highlighting chemopreventive effects of SFN.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-12184","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada. reza.mokhtari@sickkids.ca.","annee":"2017","mois":"7","numero":"","page":"","auteurs":[{"ID":12176,"post_author":"0","post_date":"2018-12-03 18:43:37","post_date_gmt":"2018-12-03 17:43:37","post_content":"","post_title":"Herman Yeger","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"herman-yeger","to_ping":"","pinged":"","post_modified":"2018-12-03 18:43:37","post_modified_gmt":"2018-12-03 17:43:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/herman-yeger\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12177,"post_author":"0","post_date":"2018-12-03 18:43:37","post_date_gmt":"2018-12-03 17:43:37","post_content":"","post_title":"Reza Bayat Mokhtari","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"reza-bayat-mokhtari","to_ping":"","pinged":"","post_modified":"2018-12-03 18:43:37","post_modified_gmt":"2018-12-03 17:43:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/reza-bayat-mokhtari\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12178,"post_author":"0","post_date":"2018-12-03 18:43:38","post_date_gmt":"2018-12-03 17:43:38","post_content":"","post_title":"Narges Baluch","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"narges-baluch","to_ping":"","pinged":"","post_modified":"2018-12-03 18:43:38","post_modified_gmt":"2018-12-03 17:43:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/narges-baluch\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12179,"post_author":"0","post_date":"2018-12-03 18:43:39","post_date_gmt":"2018-12-03 17:43:39","post_content":"","post_title":"Tina S Homayouni","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"tina-s-homayouni","to_ping":"","pinged":"","post_modified":"2018-12-03 18:43:39","post_modified_gmt":"2018-12-03 17:43:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/tina-s-homayouni\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12180,"post_author":"0","post_date":"2018-12-03 18:43:39","post_date_gmt":"2018-12-03 17:43:39","post_content":"","post_title":"Evgeniya Morgatskaya","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"evgeniya-morgatskaya","to_ping":"","pinged":"","post_modified":"2018-12-03 18:43:39","post_modified_gmt":"2018-12-03 17:43:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/evgeniya-morgatskaya\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12181,"post_author":"0","post_date":"2018-12-03 18:43:40","post_date_gmt":"2018-12-03 17:43:40","post_content":"","post_title":"Sushil Kumar","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"sushil-kumar","to_ping":"","pinged":"","post_modified":"2018-12-03 18:43:40","post_modified_gmt":"2018-12-03 17:43:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/sushil-kumar\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12182,"post_author":"0","post_date":"2018-12-03 18:43:40","post_date_gmt":"2018-12-03 17:43:40","post_content":"","post_title":"Parandis Kazemi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"parandis-kazemi","to_ping":"","pinged":"","post_modified":"2018-12-03 18:43:40","post_modified_gmt":"2018-12-03 17:43:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/parandis-kazemi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":12183,"post_author":"0","post_date":"2018-12-03 18:43:41","post_date_gmt":"2018-12-03 17:43:41","post_content":"","post_title":"Journal of cell communication and signaling","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"journal-of-cell-communication-and-signaling","to_ping":"","pinged":"","post_modified":"2018-12-03 18:43:41","post_modified_gmt":"2018-12-03 17:43:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/journal-of-cell-communication-and-signaling\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review. - Aprifel<\/title>\n<meta name=\"description\" content=\"The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review.\" \/>\n<meta property=\"og:description\" content=\"The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-role-of-sulforaphane-in-cancer-chemoprevention-and-health\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" 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