{"id":11889,"date":"2017-07-01T00:00:00","date_gmt":"2018-12-03T17:40:24","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/apple-and-blackcurrant-polyphenol-rich-drinks-decrease-postprandial\/"},"modified":"2018-12-03T18:40:24","modified_gmt":"2018-12-03T17:40:24","slug":"apple-and-blackcurrant-polyphenol-rich-drinks-decrease-postprandial","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/apple-and-blackcurrant-polyphenol-rich-drinks-decrease-postprandial\/","title":{"rendered":"Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women."},"content":{"rendered":"<p style=\"text-align:justify\">Postprandial glycemic responses to meals are inhibited by polyphenol-rich plant foods. Combinations of polyphenols may be particularly effective through complementary mechanisms. A randomized, controlled, double-blinded cross-over trial was conducted in healthy volunteers to test the hypothesis that apple and blackcurrant polyphenol-rich drinks would reduce postprandial blood glucose concentrations. Secondary outcomes included insulin and glucose-dependent insulinotropic polypeptide (GIP) secretion. Twenty men (mean age 26 y, SD 8) and 5 postmenopausal women (mean age 57 y, SD 3) consumed a placebo drink (CON) and 2 polyphenol-rich drinks containing fruit extracts: either 1200 mg apple polyphenols (AE), or 600 mg apple polyphenols+600 mg blackcurrant anthocyanins (AE+BE), in random order with a starch and sucrose meal. Incremental areas under the curve (iAUC) for plasma glucose concentrations were lower following AE+BE over 0-30 and 0-120 min compared with CON; mean differences (95% CI) -32 mmol\/L&middot;min (-41, -22, P&lt;.0005) and -52 mmol\/L min (-94, -9, P&lt;.05), respectively. AE significantly reduced iAUC 0-30 min (mean difference -26 mmol\/L min, -35, -18, P&lt;.0005) compared with CON, but the difference over 120 min was not significant. Postprandial insulin, C-peptide and GIP concentrations were significantly reduced relative to CON. A dose response inhibition of glucose transport was demonstrated in Caco-2 cells, including total and GLUT-mediated transport, and SGLT1-mediated glucose transport was strongly inhibited at all doses in Xenopus oocytes, following 10 min incubation with 0.125-4 mg apple polyphenols\/ml. In conclusion, ingestion of apple and blackcurrant polyphenols decreased postprandial glycemia, which may be partly related to inhibition of intestinal glucose transport.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-11889","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Diabetes & Nutritional Sciences Division, Faculty of Life Sciences and Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.","annee":"2017","mois":"7","numero":"49","page":"53-62","auteurs":[{"ID":11880,"post_author":"0","post_date":"2018-12-03 18:40:19","post_date_gmt":"2018-12-03 17:40:19","post_content":"","post_title":"Monica L Castro-Acosta","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"monica-l-castro-acosta","to_ping":"","pinged":"","post_modified":"2018-12-03 18:40:19","post_modified_gmt":"2018-12-03 17:40:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/monica-l-castro-acosta\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":11881,"post_author":"0","post_date":"2018-12-03 18:40:20","post_date_gmt":"2018-12-03 17:40:20","post_content":"","post_title":"Stephanie G Stone","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"stephanie-g-stone","to_ping":"","pinged":"","post_modified":"2018-12-03 18:40:20","post_modified_gmt":"2018-12-03 17:40:20","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/stephanie-g-stone\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":11882,"post_author":"0","post_date":"2018-12-03 18:40:20","post_date_gmt":"2018-12-03 17:40:20","post_content":"","post_title":"Jonathan E Mok","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jonathan-e-mok","to_ping":"","pinged":"","post_modified":"2018-12-03 18:40:20","post_modified_gmt":"2018-12-03 17:40:20","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jonathan-e-mok\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":11883,"post_author":"0","post_date":"2018-12-03 18:40:21","post_date_gmt":"2018-12-03 17:40:21","post_content":"","post_title":"Rhia K Mhajan","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rhia-k-mhajan","to_ping":"","pinged":"","post_modified":"2018-12-03 18:40:21","post_modified_gmt":"2018-12-03 17:40:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rhia-k-mhajan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":11884,"post_author":"0","post_date":"2018-12-03 18:40:21","post_date_gmt":"2018-12-03 17:40:21","post_content":"","post_title":"Chi-Ieng Fu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"chi-ieng-fu","to_ping":"","pinged":"","post_modified":"2018-12-03 18:40:21","post_modified_gmt":"2018-12-03 17:40:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/chi-ieng-fu\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":11885,"post_author":"0","post_date":"2018-12-03 18:40:22","post_date_gmt":"2018-12-03 17:40:22","post_content":"","post_title":"Georgia N Lenihan-Geels","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"georgia-n-lenihan-geels","to_ping":"","pinged":"","post_modified":"2018-12-03 18:40:22","post_modified_gmt":"2018-12-03 17:40:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/georgia-n-lenihan-geels\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":11886,"post_author":"0","post_date":"2018-12-03 18:40:22","post_date_gmt":"2018-12-03 17:40:22","post_content":"","post_title":"Christopher P Corpe","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"christopher-p-corpe","to_ping":"","pinged":"","post_modified":"2018-12-03 18:40:22","post_modified_gmt":"2018-12-03 17:40:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/christopher-p-corpe\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":11887,"post_author":"0","post_date":"2018-12-03 18:40:23","post_date_gmt":"2018-12-03 17:40:23","post_content":"","post_title":"Wendy L Hall","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"wendy-l-hall","to_ping":"","pinged":"","post_modified":"2018-12-03 18:40:23","post_modified_gmt":"2018-12-03 17:40:23","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/wendy-l-hall\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":11888,"post_author":"0","post_date":"2018-12-03 18:40:23","post_date_gmt":"2018-12-03 17:40:23","post_content":"","post_title":"The Journal of nutritional biochemistry","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"the-journal-of-nutritional-biochemistry","to_ping":"","pinged":"","post_modified":"2018-12-03 18:40:23","post_modified_gmt":"2018-12-03 17:40:23","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/the-journal-of-nutritional-biochemistry\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and incretin response to a high-carbohydrate meal in healthy men and women. - Aprifel<\/title>\n<meta name=\"description\" content=\"Apple and blackcurrant polyphenol-rich drinks decrease postprandial glucose, insulin and 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