{"id":10372,"date":"2017-09-01T00:00:00","date_gmt":"2018-12-03T17:21:57","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/nutritional-strategies-and-gut-microbiota-composition-as\/"},"modified":"2018-12-03T18:21:57","modified_gmt":"2018-12-03T17:21:57","slug":"nutritional-strategies-and-gut-microbiota-composition-as","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/nutritional-strategies-and-gut-microbiota-composition-as\/","title":{"rendered":"Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants."},"content":{"rendered":"<p style=\"text-align:justify\">Background: The pathophysiology of necrotizing enterocolitis (NEC) remains poorly understood.Objective: We assessed the relation between feeding strategies, intestinal microbiota composition, and the development of NEC.Design: We performed a prospective nationwide population-based study, EPIPAGE 2 (Etude Epid&eacute;miologique sur les Petits Ages Gestationnels), including preterm infants born at &lt;32 wk of gestation in France in 2011. From individual characteristics observed during the first week of life, we calculated a propensity score for the risk of NEC (Bell&#039;s stage 2 or 3) after day 7 of life. We analyzed the relation between neonatal intensive care unit (NICU) strategies concerning the rate of progression of enteral feeding, the direct-breastfeeding policy, and the onset of NEC using general linear mixed models to account for clustering by the NICU. An ancillary propensity-matched case-control study, EPIFLORE (Etude Epid&eacute;miologique de la flore), in 20 of the 64 NICUs, analyzed the intestinal microbiota by culture and 16S ribosomal RNA gene sequencing.Results: Among the 3161 enrolled preterm infants, 106 (3.4%; 95% CI: 2.8%, 4.0%) developed NEC. Individual characteristics were significantly associated with NEC. Slower and intermediate rates of progression of enteral feeding strategies were associated with a higher risk of NEC, with an adjusted OR of 2.3 (95% CI: 1.2, 4.5; P = 0.01) and 2.0 (95% CI: 1.1, 3.5; P = 0.02), respectively. Less favorable and intermediate direct-breastfeeding policies were associated with higher NEC risk as well, with an adjusted OR of 2.5 (95% CI: 1.1, 5.8; P = 0.03) and 2.3 (95% CI: 1.1, 4.8; P = 0.02), respectively. Microbiota analysis performed in 16 cases and 78 controls showed an association between Clostridium neonatale and Staphylococcus aureus with NEC (P = 0.001 and P = 0.002).Conclusions: A slow rate of progression of enteral feeding and a less favorable direct-breastfeeding policy are associated with an increased risk of developing NEC. For a given level of risk assessed by propensity score, colonization by C. neonatale and\/or S. aureus is significantly associated with NEC. This trial (EPIFLORE study) was registered at clinicaltrials.gov as NCT01127698.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-10372","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Neonatal Medicine, jcroze@chu-nantes.fr.","annee":"2017","mois":"9","numero":"106:3","page":"821-830","auteurs":[{"ID":10357,"post_author":"0","post_date":"2018-12-03 18:21:35","post_date_gmt":"2018-12-03 17:21:35","post_content":"","post_title":"H El Bilali","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"h-el-bilali","to_ping":"","pinged":"","post_modified":"2018-12-03 18:21:35","post_modified_gmt":"2018-12-03 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17:21:41","post_content":"","post_title":"Jean-Christophe Roz\u00e9","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jean-christophe-roze","to_ping":"","pinged":"","post_modified":"2018-12-03 18:21:41","post_modified_gmt":"2018-12-03 17:21:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jean-christophe-roze\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10361,"post_author":"0","post_date":"2018-12-03 18:21:42","post_date_gmt":"2018-12-03 17:21:42","post_content":"","post_title":"Pierre-Yves Ancel","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pierre-yves-ancel","to_ping":"","pinged":"","post_modified":"2018-12-03 18:21:42","post_modified_gmt":"2018-12-03 17:21:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pierre-yves-ancel\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10362,"post_author":"0","post_date":"2018-12-03 18:21:43","post_date_gmt":"2018-12-03 17:21:43","post_content":"","post_title":"Patricia Lepage","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"patricia-lepage","to_ping":"","pinged":"","post_modified":"2018-12-03 18:21:43","post_modified_gmt":"2018-12-03 17:21:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/patricia-lepage\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10363,"post_author":"0","post_date":"2018-12-03 18:21:45","post_date_gmt":"2018-12-03 17:21:45","post_content":"","post_title":"Laetitia Martin-Marchand","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"laetitia-martin-marchand","to_ping":"","pinged":"","post_modified":"2018-12-03 18:21:45","post_modified_gmt":"2018-12-03 17:21:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/laetitia-martin-marchand\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10364,"post_author":"0","post_date":"2018-12-03 18:21:46","post_date_gmt":"2018-12-03 17:21:46","post_content":"","post_title":"Ziad Al Nabhani","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ziad-al-nabhani","to_ping":"","pinged":"","post_modified":"2018-12-03 18:21:46","post_modified_gmt":"2018-12-03 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Picaud","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jean-charles-picaud","to_ping":"","pinged":"","post_modified":"2018-12-03 18:21:49","post_modified_gmt":"2018-12-03 17:21:49","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jean-charles-picaud\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10367,"post_author":"0","post_date":"2018-12-03 18:21:50","post_date_gmt":"2018-12-03 17:21:50","post_content":"","post_title":"Julio Aires","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"julio-aires","to_ping":"","pinged":"","post_modified":"2018-12-03 18:21:50","post_modified_gmt":"2018-12-03 17:21:50","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/julio-aires\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10368,"post_author":"0","post_date":"2018-12-03 18:21:51","post_date_gmt":"2018-12-03 17:21:51","post_content":"","post_title":"M\u00e9lanie Durox","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"melanie-durox","to_ping":"","pinged":"","post_modified":"2018-12-03 18:21:51","post_modified_gmt":"2018-12-03 17:21:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/melanie-durox\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10369,"post_author":"0","post_date":"2018-12-03 18:21:53","post_date_gmt":"2018-12-03 17:21:53","post_content":"","post_title":"Dominique Darmaun","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dominique-darmaun","to_ping":"","pinged":"","post_modified":"2018-12-03 18:21:53","post_modified_gmt":"2018-12-03 17:21:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dominique-darmaun\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10370,"post_author":"0","post_date":"2018-12-03 18:21:54","post_date_gmt":"2018-12-03 17:21:54","post_content":"","post_title":"Josef Neu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"josef-neu","to_ping":"","pinged":"","post_modified":"2018-12-03 18:21:54","post_modified_gmt":"2018-12-03 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American journal of clinical nutrition","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"the-american-journal-of-clinical-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:56","post_modified_gmt":"2018-12-03 15:01:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/the-american-journal-of-clinical-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants. - Aprifel<\/title>\n<meta name=\"description\" content=\"Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in 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