Inhibition of proliferation of a colon cancer cell line by indole-3-carbinol.

Auteur(s) :
Frydoonfar HR., Mcgrath DR., Spigelman AD.
Date :
Mai, 2002
Source(s) :
COLORECTAL DISEASE. #4:3 p205-207
Adresse :
Discipline of Surgical Science Faculty of Medicine and Health Sciences The University of Newcastle.

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OBJECTIVE:
To observe the effect of Indole-3-carbinol (I3C), a naturally occurring component of cruciferous vegetables, on cell proliferation of a colon cancer cell line.

METHODS:
Cell proliferation was measured using three different methods; 3H-thymidine incorporation, cell count and colourimetric assay.

RESULTS:
Each method of measurement revealed that I3C significantly reduced cell proliferation at concentrations of > 0.1 mM.

CONCLUSION:
The present study demonstrates for the first time the capacity of indole-3-carbinol to inhibit cell proliferation of a colon cancer cell line.

Source : Pubmed
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