Dietary Fiber Intake Reduces Risk for Colorectal Adenoma: a Meta-Analysis.

Auteur(s) :
Ben Q., Sun Y., Chai R., Qian A., Xu B., Yuan Y.
Date :
Nov, 2013
Source(s) :
Gastroenterology. # p
Adresse :
Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai 200025, China.

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OBJECTIVE
Reports on the association between dietary fiber intake and risk of colorectal adenoma (CRA), the precursor of colorectal cancer, have been inconsistent. We conducted a meta-analysis of case-control and cohort studies to analyze this association.

METHODS
We searched the MEDLINE and EMBASE databases to identify relevant studies published through July 2013. A random effects model was used to estimate summary relative risks (SRRs) and 95% confidence intervals (CIs) for associations between fiber intake and CRA risk. Heterogeneity among studies was assessed using Cochran's Q and I(2) statistics.

RESULTS
Our meta-analysis included 20 studies involving 10,948 subjects with CRA. The SRRs of CRA for total dietary fiber were 0.72 (95% CI, 0.63-0.83) in a high vs. low intake analysis and 0.91 (95% CI, 0.87-0.95) per 10-g/day increase in fiber intake in a dose-response model. Subgroup analyses indicated a significant inverse association between total fiber intake and CRA risk in case-control studies (SRR = 0.66; 95% CI, 0.56-0.77), but not in cohort studies (SRR = 0.92; 95% CI, 0.76-1.10). The SRRs of CRA were 0.84 for fruit fiber (95% CI, 0.76-0.94; n = 6 studies), 0.93 for vegetable fiber (95% CI, 0.84-1.04; n = 6studies), and 0.76 for cereal fiber (95% CI, 0.62-0.92; n = 9 studies) in high vs. low intake analyses.

CONCLUSIONS
Our findings support the hypothesis that high dietary fiber intake is inversely associated with CRA risk. Further studies with prospective designs that use validated questionnaires and control for important confounders are warranted.

Source : Pubmed
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