Cancer and ageing: rival demons?

Auteur(s) :
Campisi CAMPISI.
Date :
Juil, 2025
Source(s) :
NATURE REVIEWS CANCER. #3(5) p339-349
Adresse :
"CAMPISI J,UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB DIV LIFE SCI;1 CYCLOTRON RD; BERKELEY CA 94720, USA.jcampisi@lbl.gov "

Sommaire de l'article

Organisms with renewable tissues use a network of genetic pathways and cellular responses to prevent cancer. The main mammalian tumour-suppressor pathways evolved from ancient mechanisms that, in simple post-mitotic organisms, act predominantly to regulate embryogenesis or to protect the germline. The shift from developmental and/or germline maintenance in simple organisms to somatic maintenance in complex organisms might have evolved at a cost. Recent evidence indicates that some mammalian tumour-suppressor mechanisms contribute to ageing. How might this have happened, and what are its implications for our ability to control cancer and ageing?

Source : Pubmed
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