Beneficial effects of a dietary approaches to stop hypertension eating plan on features of the metabolic syndrome

Title: Author(s): Azadbakht L, Mirmiran P, Esmaillzadeh A, Azizi T, Azizi F
Source: DIABETES CARE 28 (12): 2823-2831 DEC 2005
Document Type: Article
Language: English
Abstract: OBJECTIVE – To determine the effects of a Dietary Approaches to Stop Hypertension (DASH) eating plan on metabolic risks in patients with the metabolic syndrome.
RESEARCH DESIGN AND METHODS – This was a randomized controlled ompatient trial conducted on 116 patients with the metabolic syndrome. Three diets were prescribed for 6 months: a control diet, a weight-reducing diet emphasizing healthy food choices, and the DASH diet with reduced calories and increased consumption of fruit, vegetables, low-fat dairy, and whole grains and lower in saturated fat, total fat, and cholesterol and restricted to 2,400 mg Na. The main outcome measures were the components of the metabolic syndrome.

RESULTS – Relative to the control diet, the DASH diet resulted in higher HDL cholesterol (7 and 10 mg/dl), lower triglycerides (- 18 and – 14 mg/dl), systolic blood pressure (SBP) (- 12 and -11 mmHg), diastolic blood pressure (- 6 and – 7 mmHg), weight (- 16 and – 14 kg), fasting blood glucose (FBG) (- 15 and -8 mg/dl), and weight (- 16 and – 15 kg), among men and women, respectively (all P < 0.001). The net reduction in triglycerides (- 17 and – 18 mg/dl), SBP (-11 and -11 mmHg), diastolic blood pressure (- 5 and – 6 mmHg), and FBG (- 4 and – 6 mg/dl), weight (- 16 and – 15 kg), and increase in HDL (5 and 10 mg/dl) among men and women, respectively, was higher in the DASH group (all P < 0.05). The weight-reducing diet resulted in significant change in triglycerides (-13 and -10 mg/dl), SBP (- 6 and – 6 mmHg), and weight (- 13 and – 12 kg) among men and women, respectively (all P < 0.05).

CONCLUSIONS – The DASH diet can likely reduce most of the metabolic risks in both men and women; the related mechanisms need further study.

KeyWords Plus: INSULIN-RESISTANCE SYNDROME; BLOOD-PRESSURE; LOW-FAT; OXIDATIVE STRESS; TEHRANIAN ADULTS; BODY-COMPOSITION; DASH DIET; OBESITY; GLUCOSE; PREVALENCE
Addresses: Azizi F (reprint author), Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, POB 19395-4763, Tehran, Iran
Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Tehran, Iran
E-mail Addresses: [email protected]

Publisher: AMER DIABETES ASSOC, 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA, http://www.diabetes.org