Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.

Auteur(s) :
Gunnell D., Maynard LM., Donovan JL., Gillatt D., Hamdy FC., Holly JM., Neal DE., Oliver SE., Pearce A., Persad R., Peters TJ.
Date :
Juin, 2003
Source(s) :
BRITISH JOURNAL OF NUTRITION. #88:11 p1682-1686
Adresse :
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, UK. [email protected]

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We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.

Source : Pubmed
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