Risk factors for choledocholithiasis in a south Indian population: a case-control study.

Auteur(s) :
Chandran AP., Sivarajan RR., Srinivas M., Srinivasan V., Venkataraman J.
Date :
Nov, 2013
Source(s) :
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology., Indian J Gastroenterol.. #32:6 p381-385
Adresse :
Department of Medicine, Stanley Medical College, Old Jail Road, Royapuram, Chennai, 600 001, India.

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AIM
To identify risk factors for common bile duct (CBD) stones in a south Indian population.

METHODS
Demographic characteristics and diet details were obtained from patients with isolated CBD stones (Gp I) and those with combined CBD and gallstones (Gp II) and age- and sex-matched controls. The risk factors were compared between the two groups.

RESULTS
The demographic characteristics were similar between the two groups and matched controls. The significant risk factors for Gp I were infrequent consumption of green vegetable (odds ratio (OR), 2.3; p < 0.05), intake of tea/coffee (OR 3.3; p < 0.01) and less consumption of sugar (p < 0.01). For Gp II, the risk factors were frequent intake (>3 times per week) of spices (OR, 2.8; p <?0.05), fried foods (OR, 2.7; p < 0.05), tamarind (OR, 2.8; p < 0.01), and quantum of oil (p < 0.01) per month. Green vegetables (OR, 8.5; p < 0.00001) and sugar (9.5 + 4.2 vs. 13.8 + 11.2 g; p < 0.00001) were protective. Between the two groups, the risk factors for Gp II were less frequent green vegetable intake (OR: 6.4; p < 0.00001), more frequent spicy food (0-3 times per week) (OR, 7.0; p < 0.05), and higher monthly oil intake (251 + 105 vs. 292 + 89 mL; p < 0.05).

CONCLUSION
CBD stones in both groups were associated with reduced intake of sugar and green vegetables. Our findings need to be validated in larger studies.

Source : Pubmed
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