{"id":84889,"date":"2022-07-04T14:30:17","date_gmt":"2022-07-04T12:30:17","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/?post_type=article_revue&#038;p=84889"},"modified":"2023-03-23T14:33:14","modified_gmt":"2023-03-23T13:33:14","slug":"antioxidant-and-chronic-kidney-disease","status":"publish","type":"article_revue","link":"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/","title":{"rendered":"Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease"},"content":{"rendered":"\n<p><strong>Numerous studies have shown health benefits of cruciferous vegetables. They contain vitamins, minerals, phenolic compounds, and more particularly sulforaphane. Sulforaphane is a sulfur-containing isothiocyanate which has numerous essential roles as an antimicrobial, antioxidant, anti-inflammatory, (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30372361\/\" target=\"_blank\" rel=\"noreferrer noopener\">Vanduchova ert al, 2019<\/a>; <a href=\"https:\/\/www.hindawi.com\/journals\/omcl\/2019\/2716870\/\" target=\"_blank\" rel=\"noreferrer noopener\">Houghton et al<\/a>.) and anti-oncogenic (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32425794\/\" target=\"_blank\" rel=\"noreferrer noopener\">Calcabrini et al, 2020<\/a>) agent and as an epigenetic modulator (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7068201\/\" target=\"_blank\" rel=\"noreferrer noopener\">Hyun et al, 2019<\/a>)<\/strong><\/p>\n\n\n\n<p><strong>Health benefits of sulforaphane have been more studied in the context of cancer and its potential preventive effects were examined on diabetes, cardiovascular and neurological diseases (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4637098\/\" target=\"_blank\" rel=\"noreferrer noopener\">Bai et al. 2015 ;<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31334360\/\" target=\"_blank\" rel=\"noreferrer noopener\"> Klomparens E et al,. 2019<\/a>)<\/strong><\/p>\n\n\n\n<p><strong>A recent review of the literature examined the potential benefits of sulforaphane against various diseases and some elements are described in this article.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-cruciferous-vegetables-source-of-sulforaphane\">Cruciferous vegetables : source of sulforaphane <\/h2>\n\n\n\n<p>Sulforaphane is a sulfur-containing isothiocyanate, formed when its precursor, glucoraphanin, an organic compound of the glucosinolate family, is transformed by an enzyme, myrosinase, as a result of damage to the plant (e.g. chewing), allowing the enzyme and its substrate to combine and react. Sulforaphane is one of the main activators of Nrf2 which neutralize oxidants.<br>Cruciferous vegetables such as broccoli, cauliflower, kale, and cabbage are rich in sulforaphane. Broccoli sprouts contain the highest concentration of sulforaphane with 1153 mg\/100 dry weight (mature broccoli contains between 44 and 171 mg\/100 g dry weight (see figure 1 relative to the glucosinolate content in cruciferous fresh vegetables)) (<a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf051823g\" target=\"_blank\" rel=\"noreferrer noopener\">Nakagawa et al., 2006<\/a>).<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"704\" height=\"481\" src=\"https:\/\/aprifel-pp.mentalworks.biz\/wp-content\/uploads\/2022\/07\/Capture-decran-2022-06-28-111135.png\" alt=\"\" class=\"wp-image-84892\"\/><figcaption>Figure 1 : Glucosinolate concentration in cruciferous fresh vegetables<\/figcaption><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\" id=\"h-litterature-on-sulforaphane-effects\">Litterature on sulforaphane effects<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Inflammation<\/strong><\/li><\/ul>\n\n\n\n<p>Inflammation and oxidative stress are intrinsically involved in the pathogenesis of chronic noncommunicable diseases such as cardiovascular disease, hypertension, obesity, chronic kidney disease, diabetes, and cancer. Accordingly, numerous nutritional strategies have been developed and applied to decrease inflammation and oxidative stress, and to improve the quality of life of affected individuals. According to studies summarized in this review, sulforaphane treatment seems to be an efficient anti-inflammatory and antioxidant strategy. Clinical studies in humans should be encouraged because only a limited number of published reports dealing with this topic currently exist in the literature. (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30954362\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mazarakis et al., 2020<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24559141\/\" target=\"_blank\" rel=\"noreferrer noopener\">Tan SM et al., 2014<\/a>)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Microbiota<\/strong><\/li><\/ul>\n\n\n\n<p>Dietary fibers and phytonutrients are known as essential modulators of the gut microbiota. Therefore, the intake of cruciferous vegetables can alter the composition of the gut microbiota and lead to the growth of specific bacteria that increase the production of sulforaphane, because gut microbiota metabolize glucosinolate to sulforaphane (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0955286318303000\" target=\"_blank\" rel=\"noreferrer noopener\">Kaczmarek et al., 2009<\/a>; <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5372925\/\" target=\"_blank\" rel=\"noreferrer noopener\">Liu X et al., 2017<\/a>).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>A modulator of ageing processes<\/strong><\/li><\/ul>\n\n\n\n<p>Accumulating evidence suggests that isothiocyanates, including sulforaphane, can counteract aspects of the ageing process via a range of underlying mechanisms, from Nrf2-dependent or independent pathways to modification of the epigenetic landscape of ageing. Given the role of Nrf2 as a geroprotective agent and mediator of ageing processes, it is tempting to speculate on the capacity of sulforaphane to prevent or mitigate the progression of ageing-related diseases (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7066546\/\" target=\"_blank\" rel=\"noreferrer noopener\">Dai et al., 2020<\/a>)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Effect on chronic kidney disease<\/strong><\/li><\/ul>\n\n\n\n<p>Sulforaphane acts as a geroprotectant, modulates the epigenetic landscape, protects against mitochondrial damage, and helps maintain a normative gut microbiota, thus suggesting a promising role for sulforaphane in the control of several diseases. In this context, patients with chronic kidney disease, a disease characterized by inflammation, oxidative stress, gut dysbiosis, mitochondrial dysfunction, and an altered epigenetic machinery, may be an ideal patient group for using food as a novel treatment strategy. Although there are no clinical studies demonstrating an effect of sulforaphane in chronic kidney disease, findings of studies in other patient groups suggest that sulforaphane could be a promising adjunctive therapy. Notably, sulforaphane therapy has already been shown to improve renal function in a range of preclinical models of renal damage. Clinical studies with patients with chronic kidney disease using sulforaphane should thus be encouraged to promote improvement in patients\u2019 quality of life.<\/p>\n\n\n\n<div class=\"block__solid-colored\">\n    <div class=\"block__solid-colored__leading\">\n        <i class=\"fa-classic fa-regular fa-square-check\" aria-hidden=\"true\"><\/i>\n        <strong>Key messages<\/strong>\n    <\/div>\n    <div class=\"block__solid-colored__content\"><ul>\n<li>Sulforaphane is an important bioactive compound present in cruciferous vegetables<\/li>\n<li>An extensive literature has shown that the main route of action of sulforaphane is by its antioxidant potential and activation of the transcription factor Nrf2, which has a key role in the antioxidant response.<\/li>\n<li>Sulforaphane acts as a geroprotectant, modulates the epigenetic landscape, protects against mitochondrial damage, and helps maintain a normative gut microbiota, thus suggesting a promising role for sulforaphane in the control of several diseases, including chronic kidney disease<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"block__stylized-list\">\n    <div class=\"block__stylized-list__leading\" id=\"block__stylized-list__leading\">\n        <i class=\"fa-classic fa-regular fa-pen-to-square\" aria-hidden=\"true\"><\/i>\n        <strong>Methodology<\/strong>\n    <\/div>\n    <div id=\"block__stylized-list__content\" style=\"display: none;\">\n<li>A total of 227 publications were included<\/li>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>Based on : <\/strong> Cardozo LFMF, et al. Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease. Nutr Rev. 2021 Oct 11;79(11):1204-1224<\/p>\n\n\n\n<div class=\"block__reference\">\n    <div class=\"block__reference__leading\" id=\"block__reference__leading\">\n        <i class=\"fa-classic fa-solid fa-share-from-square\" aria-hidden=\"true\"><\/i>\n        <strong>R\u00e9f\u00e9rences<\/strong>\n    <\/div>\n    <div class=\"block__reference__entries\" id=\"block__reference__entries\" style=\"display: none;\">\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Bai Y, et al. Sulforaphane protection against the development of doxorubicin-induced chronic heart failure is associated with Nrf2 Upregulation. Oxid Med Cell Longev. 2015;2015:1\u201313.<\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Calcabrini C, et al. Sulforaphane potentiates anticancer effects of doxorubicin and cisplatin and mitigates their toxic effects. Front Pharmacol. 2020;11:doi: 10.3389\/fphar.2020.00567.<\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Dai L, et al..Nephrol Dial Transplant. Early vascular ageing in chronic kidney disease: impact of inflammation, vitamin K, senescence and genomic damage. 2020;35:Ii31\u2013ii37. <\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Houghton CA. Sulforaphane: its \u201ccoming of age\u201d as a clinically relevant nutraceutical in the prevention and treatment of chronic disease. Oxid Med Cell Longev.2019;2019:1\u201327<\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Hyun TK. A recent overview on sulforaphane as a dietary epigenetic modulator. Excli J. 2020;19:131\u2013134<\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Klomparens E, Ding Y. The neuroprotective mechanisms and effects of sulforaphane. Brain Circ. 2019;5:74\u201383<\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Mazarakis N, et al. The potential use of L-sulforaphane for the treatment of chronic inflammatory diseases: a review of the clinical evidence. Clin Nutr. 2020;39:664\u2013675<\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Nakagawa K, Umeda T, Higuchi O, et al. Evaporative light-scattering analysis of sulforaphane in broccoli samples: quality of broccoli products regarding sulforaphane contents. J Agric Food Chem. 2006;54:2479\u20132483<\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Tan SM, de Haan JB. . Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much? Redox Rep. 2014;19:107\u2013117<\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Vanduchova A, Anzenbacher P, Anzenbacherova E. E. Isothiocyanate from broccoli, sulforaphane, and its properties. J Med Food.  2019;22:121\u2013126.<\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Kaczmarek JL, Liu X, Charron CS, et al. Broccoli consumption affects the human gastrointestinal microbiota. J Nutr Biochem. 2019;63:27\u201334. 163. <\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Li F, Hullar MAJ, Schwarz Y, et al. Human gut bacterial communities are altered by addition of cruciferous vegetables to a controlled fruit- and vegetable-free diet. J Nutr. 2009;139:1685\u20131691. 164<\/span>\n            <\/div>\n                    <div class=\"block__reference__entry\">\n                <i class=\"fa-classic fa-solid fa-share\" aria-hidden=\"true\"><\/i>\n                <span>Liu X, Wang Y, Hoeflinger JL, et al. Dietary broccoli alters rat cecal microbiota to improve glucoraphanin hydrolysis to bioactive isothiocyanates. Nutrients. 2017;9:262<\/span>\n            <\/div>\n            <\/div>\n<\/div>\n","protected":false},"template":"","class_list":["post-84889","article_revue","type-article_revue","status-publish","hentry"],"acf":{"auteur":"","source":"","revue":[{"ID":84821,"post_author":"25","post_date":"2022-07-01 16:25:15","post_date_gmt":"2022-07-01 14:25:15","post_content":"<!-- wp:image {\"id\":84456,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n<figure class=\"wp-block-image size-full\"><img src=\"https:\/\/aprifel-pp.mentalworks.biz\/wp-content\/uploads\/2022\/06\/Edito-ok-1.jpg\" alt=\"\" class=\"wp-image-84456\"\/><\/figure>\n<!-- \/wp:image -->\n\n<!-- wp:paragraph -->\n<p><strong>Countless studies are constantly being carried out, and no two are alike. Here is an overview of three studies exploring unusual targets of fruit and vegetable consumption.<\/strong><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul><li>The first study dealt with inflammatory bowel disease (IBD), which encompasses Crohn\u2019s disease and ulcerative colitis (UC). The cause of these two conditions is unknown although the mechanism involved has been identified, with a strong inflammatory component. Data suggest that diet may trigger, aggravate or even favour them. Consumption of fibre was associated with a slight reduction in the risk of Crohn\u2019s disease, while fruit and vegetable consumption was linked to a decrease in Crohn\u2019s disease and UC. This may have been due to the anti-inflammatory effects of fruit and vegetables, their impact on the microbiota, or a favourable effect of the associated eating style (less fat and sugar, etc.?). However, especially in the case-control studies, reverse causality could not be ruled out considering that the IBD patients reduced their consumption of produce during flare-ups.<\/li><li>The second study focused on sulforaphane and foods high in it (i.e. cabbage and other cruciferous vegetables), and reviewed its effects on various diseases (inflammation, carcinogenesis, the microbiota, ageing processes, chronic kidney disease). Findings suggest that this compound, and therefore foods high in it, may be beneficial for patients with chronic kidney failure.<\/li><li>The third publication reviewed various candidate nutrients for preventing female infertility, which is a genuine public health problem that seems to be worsening, either because of the increasing age of women wanting to have children or due to unfavourable changes in the eating or lifestyle (smoking, etc.) habits of these women. Oxidative stress seems to be involved in reducing female fertility (and also male fertility). And yet a large number of well-known nutrients with antioxidant effects are widely found in fruit and vegetables (vitamins C, E and A, carotenoids, polyphenols, etc.). The authors are in favour of undertaking clinical studies to provide evidence supporting this assumption and encourage the use of antioxidants in cases of infertility. As a precautionary measure, instead of advocating food supplements, it would be safer to propose fruit and vegetables.<\/li><\/ul>\n<!-- \/wp:list -->\n\n<!-- wp:paragraph -->\n<p>Fruit and vegetables are therefore a safe bet for a growing number of health benefits.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:acf\/pictureable {\"id\":\"block_62bf0243dac96\",\"name\":\"acf\/pictureable\",\"data\":{\"authors_0_fully_name\":\"Jean Michel Lecerf\",\"_authors_0_fully_name\":\"field_pictureable_author_fully_name\",\"authors_0_profession\":\"Doctor\",\"_authors_0_profession\":\"field_pictureable_author_profession\",\"authors_0_information\":\"Nutrition \\u0026 Physical Activity Department Preventive Health and Longevity Centre, Institut Pasteur de Lille, FRANCE\",\"_authors_0_information\":\"field_pictureable_author_information\",\"authors_0_picture\":84447,\"_authors_0_picture\":\"field_pictureable_author_picture\",\"authors\":1,\"_authors\":\"field_pictureable_authors\"},\"align\":\"center\",\"mode\":\"auto\"} \/-->\n\n<!-- wp:acf\/about {\"id\":\"block_62bf027cdac97\",\"name\":\"acf\/about\",\"data\":{\"title\":\"About the author\",\"_title\":\"field_about_title\",\"content\":\"Dr. Jean-Michel Lecerf is a specialist in endocrinology and metabolic diseases. He has been a clinician at the Lille University Hospital, in lipidology, for more than 30 years. He has also been the head of the Nutrition Department at the Pasteur Institute of Lille since 1982, where he conducts applied research, public health and teaching in the field of nutrition. He is the author of numerous scientific publications and about 20 books on nutrition, cholesterol, obesity, diabetes, and metabolism.\",\"_content\":\"field_about_content\"},\"align\":\"center\",\"mode\":\"auto\"} \/-->","post_title":"74 - June 2022","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"health-benefits-of-fruit-and-vegetables-across-the-board","to_ping":"","pinged":"","post_modified":"2024-10-24 17:20:19","post_modified_gmt":"2024-10-24 15:20:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/?post_type=revue&#038;p=84821","menu_order":57,"post_type":"revue","post_mime_type":"","comment_count":"0","filter":"raw"}],"position":"3","references":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Antioxidant and chronic kidney disease<\/title>\n<meta name=\"description\" content=\"Numerous studies have shown health benefits of cruciferous vegetables. They contain vitamins, minerals, antioxidants, and more particularly sulforaphane.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease \u00c9quation Nutrition\" \/>\n<meta property=\"og:description\" content=\"Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease \u00c9quation Nutrition\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-23T13:33:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.aprifel.com\/wp-content\/uploads\/2022\/07\/Capture-decran-2022-06-28-111135.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/\",\"name\":\"Antioxidant and chronic kidney disease\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/aprifel-pp.mentalworks.biz\/wp-content\/uploads\/2022\/07\/Capture-decran-2022-06-28-111135.png\",\"datePublished\":\"2022-07-04T12:30:17+00:00\",\"dateModified\":\"2023-03-23T13:33:14+00:00\",\"description\":\"Numerous studies have shown health benefits of cruciferous vegetables. They contain vitamins, minerals, antioxidants, and more particularly sulforaphane.\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/#primaryimage\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/wp-content\/uploads\/2022\/07\/Capture-decran-2022-06-28-111135.png\",\"contentUrl\":\"https:\/\/aprifel-pp.mentalworks.biz\/wp-content\/uploads\/2022\/07\/Capture-decran-2022-06-28-111135.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.aprifel.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Antioxidant and chronic kidney disease","description":"Numerous studies have shown health benefits of cruciferous vegetables. They contain vitamins, minerals, antioxidants, and more particularly sulforaphane.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/","og_locale":"en_US","og_type":"article","og_title":"Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease \u00c9quation Nutrition","og_description":"Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease \u00c9quation Nutrition","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/","og_site_name":"Aprifel","article_modified_time":"2023-03-23T13:33:14+00:00","og_image":[{"url":"https:\/\/www.aprifel.com\/wp-content\/uploads\/2022\/07\/Capture-decran-2022-06-28-111135.png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/","name":"Antioxidant and chronic kidney disease","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/#primaryimage"},"image":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/aprifel-pp.mentalworks.biz\/wp-content\/uploads\/2022\/07\/Capture-decran-2022-06-28-111135.png","datePublished":"2022-07-04T12:30:17+00:00","dateModified":"2023-03-23T13:33:14+00:00","description":"Numerous studies have shown health benefits of cruciferous vegetables. They contain vitamins, minerals, antioxidants, and more particularly sulforaphane.","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/#primaryimage","url":"https:\/\/aprifel-pp.mentalworks.biz\/wp-content\/uploads\/2022\/07\/Capture-decran-2022-06-28-111135.png","contentUrl":"https:\/\/aprifel-pp.mentalworks.biz\/wp-content\/uploads\/2022\/07\/Capture-decran-2022-06-28-111135.png"},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/en\/global-fv-newsletter-article\/antioxidant-and-chronic-kidney-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.aprifel.com\/en\/"},{"@type":"ListItem","position":2,"name":"Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease"}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/en\/wp-json\/wp\/v2\/article_revue\/84889"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/en\/wp-json\/wp\/v2\/article_revue"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/en\/wp-json\/wp\/v2\/types\/article_revue"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/en\/wp-json\/wp\/v2\/media?parent=84889"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}